ID   A20_VARV                Reviewed;         426 AA.
AC   P0DTP7; P33843;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=DNA polymerase processivity factor component A20;
GN   ORFNames=A20R, A21R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Plays an essential role in viral DNA replication by acting as
CC       the polymerase processivity factor together with protein D4. May serve
CC       as a bridge which links the DNA polymerase E9 and the uracil DNA
CC       glycosylase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase catalytic subunit E9.
CC       Interacts with UDG. Component of the Uracil-DNA glycosylase(UDG)-A20-
CC       polymerase complex; A20 and UDG form a heterodimeric processivity
CC       factor that associates with E9 to form the processive polymerase
CC       holoenzyme. Interacts with D5 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses A20 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60873.1; -; Genomic_DNA.
DR   PIR; T28563; T28563.
DR   RefSeq; NP_042169.1; NC_001611.1.
DR   SMR; P0DTP7; -.
DR   GeneID; 1486497; -.
DR   KEGG; vg:1486497; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR010267; Chordopox_A20R.
DR   Pfam; PF05941; Chordopox_A20R; 1.
PE   3: Inferred from homology;
KW   DNA replication.
FT   CHAIN           1..426
FT                   /note="DNA polymerase processivity factor component A20"
FT                   /id="PRO_0000448159"
SQ   SEQUENCE   426 AA;  49088 MW;  6CD83C0903EBBF59 CRC64;
     MTSSADLTNL KELLSLYKSL RFSDSAAIEK YNSLVEWGTS TYWKIGVQKV ANVETSISDY
     YDEVKNKPFN IDPGYYIFLP VYFGSVFIYS KGKNMVELGS GNSFQIPDDM RSVCNKVLDG
     DNGIDFLRFV LLNNRWIMED AISKYQSPVN IFKLASEYGL NIPNYLEIEI EEDTLFDDEL
     YSIIERSFDD NFPKISISYI KLGELRRQVV DFFKFSFMYI ESIKVDRIGD NIFIPSVITK
     SGKKILVKDV DHLIRSKVRE HTFVKVKKKN TFSILYDYDG NGTETRGEVI KRIIDTIGRD
     YYVNGKYFSK VGSAGLKQLT NKLNINECTT VDELVDEINK SGTVKRKIKT QSAFDLSREC
     LGYPEADFIT LVNNMRFKIE NCKVVNFNIE NTNCLNNPSI ETIYGNFNQF VSIFNIVTDV
     KKRLFE