ID   ARP2_XENTR              Reviewed;         394 AA.
AC   Q5BL41;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Actin-related protein 2;
DE   AltName: Full=Actin-like protein 2;
GN   Name=actr2; Synonyms=arp2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein
CC       complex that mediates actin polymerization upon stimulation by
CC       nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex
CC       mediates the formation of branched actin networks in the cytoplasm,
CC       providing the force for cell motility (By similarity). Seems to contact
CC       the pointed end of the daughter actin filament (By similarity). In
CC       addition to its role in the cytoplasmic cytoskeleton, the Arp2/3
CC       complex also promotes actin polymerization in the nucleus, thereby
CC       regulating gene transcription and repair of damaged DNA (By
CC       similarity). The Arp2/3 complex promotes homologous recombination (HR)
CC       repair in response to DNA damage by promoting nuclear actin
CC       polymerization, leading to drive motility of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250|UniProtKB:P61160,
CC       ECO:0000250|UniProtKB:Q7ZTP2}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex composed of actr2/arp2,
CC       actr3/arp3, arpc1b, arpc2, arpc3, arpc4 and arpc5.
CC       {ECO:0000250|UniProtKB:Q7ZTP2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q7ZTP2}. Cell projection
CC       {ECO:0000250|UniProtKB:Q7ZTP2}. Nucleus {ECO:0000250|UniProtKB:Q7ZTP2}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP2 subfamily. {ECO:0000305}.
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DR   EMBL; BC090611; AAH90611.1; -; mRNA.
DR   RefSeq; NP_001025569.1; NM_001030398.1.
DR   AlphaFoldDB; Q5BL41; -.
DR   SMR; Q5BL41; -.
DR   STRING; 8364.ENSXETP00000030571; -.
DR   PaxDb; Q5BL41; -.
DR   DNASU; 594957; -.
DR   GeneID; 594957; -.
DR   KEGG; xtr:594957; -.
DR   CTD; 10097; -.
DR   eggNOG; KOG0677; Eukaryota.
DR   HOGENOM; CLU_027965_0_0_1; -.
DR   InParanoid; Q5BL41; -.
DR   OMA; WDDMKYL; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; Q5BL41; -.
DR   TreeFam; TF300467; -.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014001; Expressed in brain and 21 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; ISS:UniProtKB.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; ATP-binding; Cell projection; Cytoplasm; Cytoskeleton;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..394
FT                   /note="Actin-related protein 2"
FT                   /id="PRO_0000327251"
FT   BINDING         160..162
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:A7MB62"
FT   BINDING         214..218
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:A7MB62"
FT   BINDING         305..310
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:A7MB62"
SQ   SEQUENCE   394 AA;  44716 MW;  1A1D5876A2A1E541 CRC64;
     MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPV IRSTAKVGNI EIKDLMVGDE
     ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRDCKILLT EPPMNPTKNR
     EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG DGVTHICPVY EGFSLPHLTR
     RLDIAGRDIT RYLIKLLLLR GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL
     VESYTLPDGR VIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRPEFYKH
     IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR KHMVFLGGAV
     LADIMKDKDN FWMTRQEYQE KGTRVLEKLG VTVR