ID   ARP3B_MOUSE             Reviewed;         418 AA.
AC   Q641P0; Q7TSH1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Actin-related protein 3B;
DE   AltName: Full=ARP3-beta;
DE   AltName: Full=Actin-like protein 3B;
GN   Name=Actr3b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Plays a role in the organization of the actin cytoskeleton.
CC       May function as ATP-binding component of the Arp2/3 complex which is
CC       involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks. May decrease the metastatic potential of
CC       tumors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Arp2/3 complex composed of ARP2, ARP3,
CC       ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
CC       ARPC5/p16-ARC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       projection {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q641P0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q641P0-2; Sequence=VSP_034419;
CC   -!- SIMILARITY: Belongs to the actin family. ARP3 subfamily. {ECO:0000305}.
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DR   EMBL; BC053106; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC082279; AAH82279.1; -; mRNA.
DR   CCDS; CCDS19136.1; -. [Q641P0-1]
DR   CCDS; CCDS80232.1; -. [Q641P0-2]
DR   RefSeq; NP_001004365.1; NM_001004365.2. [Q641P0-1]
DR   RefSeq; NP_001297433.1; NM_001310504.1. [Q641P0-2]
DR   AlphaFoldDB; Q641P0; -.
DR   SMR; Q641P0; -.
DR   BioGRID; 232471; 1.
DR   IntAct; Q641P0; 3.
DR   MINT; Q641P0; -.
DR   STRING; 10090.ENSMUSP00000085578; -.
DR   iPTMnet; Q641P0; -.
DR   PhosphoSitePlus; Q641P0; -.
DR   SwissPalm; Q641P0; -.
DR   EPD; Q641P0; -.
DR   jPOST; Q641P0; -.
DR   MaxQB; Q641P0; -.
DR   PaxDb; Q641P0; -.
DR   PeptideAtlas; Q641P0; -.
DR   PRIDE; Q641P0; -.
DR   ProteomicsDB; 283244; -. [Q641P0-1]
DR   ProteomicsDB; 283245; -. [Q641P0-2]
DR   DNASU; 242894; -.
DR   Ensembl; ENSMUST00000088244; ENSMUSP00000085578; ENSMUSG00000056367. [Q641P0-1]
DR   Ensembl; ENSMUST00000128727; ENSMUSP00000121629; ENSMUSG00000056367. [Q641P0-2]
DR   GeneID; 242894; -.
DR   KEGG; mmu:242894; -.
DR   UCSC; uc008wtc.1; mouse. [Q641P0-1]
DR   CTD; 57180; -.
DR   MGI; MGI:2661120; Actr3b.
DR   VEuPathDB; HostDB:ENSMUSG00000056367; -.
DR   eggNOG; KOG0678; Eukaryota.
DR   GeneTree; ENSGT00940000158304; -.
DR   HOGENOM; CLU_027965_3_0_1; -.
DR   InParanoid; Q641P0; -.
DR   OMA; YLPPCVV; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; Q641P0; -.
DR   TreeFam; TF300644; -.
DR   BioGRID-ORCS; 242894; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Actr3b; mouse.
DR   PRO; PR:Q641P0; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q641P0; protein.
DR   Bgee; ENSMUSG00000056367; Expressed in Ammon's horn and 181 other tissues.
DR   Genevisible; Q641P0; MM.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Alternative splicing; ATP-binding; Cell projection;
KW   Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..418
FT                   /note="Actin-related protein 3B"
FT                   /id="PRO_0000342359"
FT   VAR_SEQ         1..88
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034419"
SQ   SEQUENCE   418 AA;  47580 MW;  3A9E34AF53F2345A CRC64;
     MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR VLRGVDDLDF
     FIGDEAIDKP TYATKWPIRH GIVEDWDLME RFMEQVVFKY LRAEPEDHYF LMTEPPLNTP
     ENREYLAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV
     AEGYVIGSCI KHIPIAGRDI TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVR
     EFAKYDVDPR KWIKQYTGIN AINQKKFIID VGYERFLGPE IFFHPEFANP DFMESISDVV
     DEVIQSCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLKLS QELSGGRIKP
     KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY EEYGPSICRH NPVFGVMS