ARP3C_HUMAN
ID ARP3C_HUMAN Reviewed; 210 AA.
AC Q9C0K3; Q5CZI4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Actin-related protein 3C;
DE AltName: Full=Actin-related protein 11;
DE Flags: Precursor;
GN Name=ACTR3C; Synonyms=ARP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059;
RA Shindo-Okada N., Shimizu K.;
RT "Isolation of a novel actin-related gene expressed in low-metastatic PC-14
RT human lung adenocarcinoma.";
RL Biochem. Biophys. Res. Commun. 280:61-67(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May play a role in the suppression of metastatic potential in
CC lung adenoma carcinoma cells. {ECO:0000269|PubMed:11162478}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0K3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0K3-2; Sequence=VSP_032218;
CC -!- TISSUE SPECIFICITY: Expressed in kidney, stomach, spleen, bone marrow,
CC uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal
CC liver, and fetal kidney, but not detected in small intestine, brain,
CC and thymus. Expressed in low-metastatic lung adenocarcinoma cells but
CC not in high-metastatic ones. {ECO:0000269|PubMed:11162478}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AB039791; BAB21501.1; -; mRNA.
DR EMBL; BX640643; CAI56711.1; -; mRNA.
DR CCDS; CCDS47744.1; -. [Q9C0K3-1]
DR PIR; JC7580; JC7580.
DR RefSeq; NP_001157930.1; NM_001164458.1. [Q9C0K3-1]
DR RefSeq; NP_001157931.1; NM_001164459.1. [Q9C0K3-1]
DR RefSeq; XP_011514808.1; XM_011516506.2. [Q9C0K3-1]
DR RefSeq; XP_011514809.1; XM_011516507.2. [Q9C0K3-1]
DR RefSeq; XP_011514810.1; XM_011516508.2. [Q9C0K3-1]
DR RefSeq; XP_016868038.1; XM_017012549.1. [Q9C0K3-1]
DR AlphaFoldDB; Q9C0K3; -.
DR SMR; Q9C0K3; -.
DR BioGRID; 576126; 8.
DR IntAct; Q9C0K3; 4.
DR STRING; 9606.ENSP00000252071; -.
DR iPTMnet; Q9C0K3; -.
DR PhosphoSitePlus; Q9C0K3; -.
DR BioMuta; ACTR3C; -.
DR DMDM; 74739414; -.
DR jPOST; Q9C0K3; -.
DR MassIVE; Q9C0K3; -.
DR MaxQB; Q9C0K3; -.
DR PaxDb; Q9C0K3; -.
DR PeptideAtlas; Q9C0K3; -.
DR PRIDE; Q9C0K3; -.
DR ProteomicsDB; 80071; -. [Q9C0K3-1]
DR Antibodypedia; 66353; 6 antibodies from 6 providers.
DR DNASU; 653857; -.
DR Ensembl; ENST00000252071.8; ENSP00000252071.4; ENSG00000106526.11. [Q9C0K3-1]
DR Ensembl; ENST00000683684.1; ENSP00000507618.1; ENSG00000106526.11. [Q9C0K3-1]
DR GeneID; 653857; -.
DR KEGG; hsa:653857; -.
DR MANE-Select; ENST00000683684.1; ENSP00000507618.1; NM_001164458.2; NP_001157930.1.
DR UCSC; uc003wgu.3; human. [Q9C0K3-1]
DR CTD; 653857; -.
DR DisGeNET; 653857; -.
DR GeneCards; ACTR3C; -.
DR HGNC; HGNC:37282; ACTR3C.
DR HPA; ENSG00000106526; Tissue enhanced (parathyroid).
DR neXtProt; NX_Q9C0K3; -.
DR OpenTargets; ENSG00000106526; -.
DR PharmGKB; PA165617588; -.
DR VEuPathDB; HostDB:ENSG00000106526; -.
DR eggNOG; KOG0678; Eukaryota.
DR GeneTree; ENSGT00940000158304; -.
DR InParanoid; Q9C0K3; -.
DR OMA; PLMCIVH; -.
DR OrthoDB; 1765235at2759; -.
DR PhylomeDB; Q9C0K3; -.
DR TreeFam; TF300644; -.
DR PathwayCommons; Q9C0K3; -.
DR SignaLink; Q9C0K3; -.
DR BioGRID-ORCS; 653857; 54 hits in 1008 CRISPR screens.
DR ChiTaRS; ACTR3C; human.
DR GenomeRNAi; 653857; -.
DR Pharos; Q9C0K3; Tdark.
DR PRO; PR:Q9C0K3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9C0K3; protein.
DR Bgee; ENSG00000106526; Expressed in right lobe of liver and 107 other tissues.
DR ExpressionAtlas; Q9C0K3; baseline and differential.
DR Genevisible; Q9C0K3; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; ATP-binding; Nucleotide-binding;
KW Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..210
FT /note="Actin-related protein 3C"
FT /id="PRO_0000324333"
FT VAR_SEQ 1..163
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032218"
FT CONFLICT 189
FT /note="M -> V (in Ref. 2; CAI56711)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 23712 MW; AB94A33B440CD35B CRC64;
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC
IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP
QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI
DVRRPLYKME QIPLSYPQGH GFHPLSPPFH
