NUOL_RICBR
ID NUOL_RICBR Reviewed; 642 AA.
AC Q1RKE6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=NADH-quinone oxidoreductase subunit L;
DE EC=7.1.1.-;
DE AltName: Full=NADH dehydrogenase I subunit L;
DE AltName: Full=NDH-1 subunit L;
GN Name=nuoL; OrderedLocusNames=RBE_0087;
OS Rickettsia bellii (strain RML369-C).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX NCBI_TaxID=336407;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RML369-C;
RX PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA Fournier P.-E., Claverie J.-M., Raoult D.;
RT "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT gene exchanges between intracellular pathogens.";
RL PLoS Genet. 2:733-744(2006).
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC (Fe-S) centers, to quinones in the respiratory chain. Couples the redox
CC reaction to proton translocation (for every two electrons transferred,
CC four hydrogen ions are translocated across the cytoplasmic membrane),
CC and thus conserves the redox energy in a proton gradient (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; CP000087; ABE04168.1; -; Genomic_DNA.
DR RefSeq; WP_011476783.1; NC_007940.1.
DR AlphaFoldDB; Q1RKE6; -.
DR SMR; Q1RKE6; -.
DR STRING; 336407.RBE_0087; -.
DR EnsemblBacteria; ABE04168; ABE04168; RBE_0087.
DR KEGG; rbe:RBE_0087; -.
DR eggNOG; COG1009; Bacteria.
DR HOGENOM; CLU_007100_6_0_5; -.
DR OMA; LIGFWQH; -.
DR OrthoDB; 1274678at2; -.
DR Proteomes; UP000001951; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; NAD; Quinone; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..642
FT /note="NADH-quinone oxidoreductase subunit L"
FT /id="PRO_0000287835"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 642 AA; 71911 MW; EEB9B220C02E6A66 CRC64;
MYKSIAIMII LLPLASALIN GLFVRRIDKK LASIVATSFL SLSALFALII FYHTGLNGHI
IHIKLLPWIE VSQFKVDWSI YIDQLTSIMF IAVTWVSSVV HIYSLGYMSR DKGIVRFLSF
LSLFTFFMLM LVSADNFLQL FFGWEGVGIC SYLLIGFWYS KESANKAAIK AFIANRVGDF
AFILGVITII FYCHSANYED VFLLAPKLAN TKILLADFEI SILDIACLLL FIGCMGKSAQ
IGLHVWLPDA MEGPTPVSAL IHAATMVTAG VFLVARCSYL FEYSPMVLQF ITIIGGITCL
FAASIAIMQN DIKKIIAYST CSQLGYMFMA CGVSAYNSGI FHLVTHAFFK ALLFLSAGSV
IHAVHEQDIF KMGELRNKMP ITYGNFLIGS LALIGIYPLA GFYSKDSILE AAYSSGSFMF
IFGILAAILT AIYSMKIIML VFHGKTRLEK DVFEHAHEPP KVMNNPLTLL VAGSFFSGMI
GYYLLSMDKP NGYFHDSLLN LHAYKLLITH PPLHIKLLPM VVGIIGIVVG IYLYKSDVVM
SFLRRQESSK DNYFTKILIN KYYFDELYNF LIVKPINCLA CLFYSGDQKI IDRFGPNGFA
RSVNCFSRLT GKTQTGYVFN YTLYVVLFVV VTISYFVWLV AV
