NUOL_RICCN
ID NUOL_RICCN Reviewed; 657 AA.
AC Q92G97;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=NADH-quinone oxidoreductase subunit L;
DE EC=7.1.1.-;
DE AltName: Full=NADH dehydrogenase I subunit L;
DE AltName: Full=NDH-1 subunit L;
GN Name=nuoL; OrderedLocusNames=RC1226;
OS Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=272944;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC (Fe-S) centers, to quinones in the respiratory chain. Couples the redox
CC reaction to proton translocation (for every two electrons transferred,
CC four hydrogen ions are translocated across the cytoplasmic membrane),
CC and thus conserves the redox energy in a proton gradient (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL03764.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE006914; AAL03764.1; ALT_INIT; Genomic_DNA.
DR PIR; B97853; B97853.
DR RefSeq; WP_041471749.1; NC_003103.1.
DR AlphaFoldDB; Q92G97; -.
DR SMR; Q92G97; -.
DR EnsemblBacteria; AAL03764; AAL03764; RC1226.
DR KEGG; rco:RC1226; -.
DR PATRIC; fig|272944.4.peg.1405; -.
DR HOGENOM; CLU_007100_6_0_5; -.
DR OMA; LIGFWQH; -.
DR Proteomes; UP000000816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; NAD; Quinone; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..657
FT /note="NADH-quinone oxidoreductase subunit L"
FT /id="PRO_0000118222"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 657 AA; 73327 MW; 21326DC83CFE42DC CRC64;
MMYQNICIMI IMLPLASSII NGLFLRVIDK KLAQVIATGF LSLSALFSLI IFCDTGLDGN
IIHIKLLPWI EVGTFKVNWS IYIDQLTSIM FIAVTWVSSI VHIYSLGYMA EDKGIIRFLS
FLSLFTFFML MLVSSDNFLQ LFFGWEGVGV CSYLLIGFWY SKESANKAAI KAFIINRASD
FAFILGVITI IVYCGSANYK DVLSSAELLS NIKIFLHFSI LDIICLLLFI GCMGKSAQIG
LHVWLPDAME GPTPVSALIH AATMVTAGVF LVARCSYLFE YSPLILQFIT IIGGVTCLFA
ASIAIMHSDI KKIIAYSTCS QLGYMFMACG VSAYNSGIFH LVTHAFFKAL LFLSAGSVIH
AVHEQDIFKM GDLRNKMPVT YGNFLIGSLA LIGIYPLAGF YSKDSILEAA YSSGSFMFIF
GIAAAILTAI YSMKIIMLVF HGKTKLEKDV FEHAHEPAKV MNNPLILLVV GSFFSGMIGY
YLLAMDKPNG YFHASLFNLH IYKLLISHPP LYIKLLPMAV GIVGIVTGIY LYKSSTVMSF
PQKRKSSKNI KNAWILRSSR GMTPLVLISN ILRNKYYFDE IYNCLIVKPI NCLASLFYLG
DQQIIDRFGP NGFSRVVNCF SVLTGKIQTG YVFNYALYIV SFIVVTISYF VWKNIMY
