ARP4_ARATH
ID ARP4_ARATH Reviewed; 441 AA.
AC Q84M92; Q8LAI7; Q8LKR2; Q9LPQ9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Actin-related protein 4 {ECO:0000303|PubMed:11891255};
GN Name=ARP4 {ECO:0000303|PubMed:11891255};
GN OrderedLocusNames=At1g18450 {ECO:0000312|Araport:AT1G18450};
GN ORFNames=F15H18.8 {ECO:0000312|EMBL:AAF25998.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, TISSUE SPECIFICITY, AND GENE
RP FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=11891255; DOI=10.1104/pp.010906;
RA McKinney E.C., Kandasamy M.K., Meagher R.B.;
RT "Arabidopsis contains ancient classes of differentially expressed actin-
RT related protein genes.";
RL Plant Physiol. 128:997-1007(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP TISSUE SPECIFICITY, INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12609034; DOI=10.1046/j.1365-313x.2003.01691.x;
RA Kandasamy M.K., McKinney E.C., Meagher R.B.;
RT "Cell cycle-dependent association of Arabidopsis actin-related proteins
RT AtARP4 and AtARP7 with the nucleus.";
RL Plant J. 33:939-948(2003).
RN [8]
RP SUBCELLULAR LOCATION, REVIEW, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15063870; DOI=10.1016/j.tplants.2004.02.004;
RA Kandasamy M.K., Deal R.B., McKinney E.C., Meagher R.B.;
RT "Plant actin-related proteins.";
RL Trends Plant Sci. 9:196-202(2004).
RN [9]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15743449; DOI=10.1111/j.1365-313x.2005.02345.x;
RA Kandasamy M.K., Deal R.B., McKinney E.C., Meagher R.B.;
RT "Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has
RT multiple effects on plant development, including early flowering and
RT delayed floral senescence.";
RL Plant J. 41:845-858(2005).
RN [10]
RP IDENTIFICATION IN THE NUA4 COMPLEX AND IN THE SWR1 COMPLEX, INTERACTION
RP WITH THE SWI/SNF COMPLEX, AND INTERACTION WITH EAF1A AND EAF1B.
RX DOI=10.1186/s12870-015-0461-1;
RA Bieluszewski T., Galganski L., Sura W., Bieluszewska A., Abram M.,
RA Ludwikow A., Ziolkowski P., Sadowski J.;
RT "AtEAF1 is a potential platform protein for Arabidopsis NuA4
RT acetyltransferase complex.";
RL BMC Plant Biol. 15:0-0(2015).
CC -!- FUNCTION: Involved in several developmental processes including
CC organization of plant organs, flowering time, anther development,
CC flower senescence and fertility, probably by regulating the chromatin
CC structure. {ECO:0000269|PubMed:15743449}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC NuA4 histone acetyltransferase complex. Interacts with the SWI/SNF
CC complex. Interacts with EAF1A and EAF1B. {ECO:0000269|Ref.10}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12609034,
CC ECO:0000269|PubMed:15063870, ECO:0000269|PubMed:15743449}. Cytoplasm
CC {ECO:0000269|PubMed:12609034}. Note=Localized in the nucleus during the
CC interphase, but is released into the cytoplasm during the mitotic phase
CC (PubMed:12609034).
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers, and, to a lower
CC extent, in roots, seedlings, leaves and siliques (at protein level).
CC {ECO:0000269|PubMed:11891255, ECO:0000269|PubMed:12609034}.
CC -!- INDUCTION: Before cytokinesis. {ECO:0000269|PubMed:12609034}.
CC -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF25998.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g18440 and At1g18450.; Evidence={ECO:0000305};
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DR EMBL; AF507912; AAM53244.1; -; mRNA.
DR EMBL; AC013354; AAF25998.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29715.1; -; Genomic_DNA.
DR EMBL; BT006474; AAP21282.1; -; mRNA.
DR EMBL; AK228098; BAF00057.1; -; mRNA.
DR EMBL; AY087788; AAM65324.1; -; mRNA.
DR EMBL; BK000422; DAA00027.1; -; Genomic_DNA.
DR PIR; C86318; C86318.
DR RefSeq; NP_564051.1; NM_101702.4.
DR AlphaFoldDB; Q84M92; -.
DR SMR; Q84M92; -.
DR BioGRID; 23664; 101.
DR STRING; 3702.AT1G18450.1; -.
DR iPTMnet; Q84M92; -.
DR PaxDb; Q84M92; -.
DR PRIDE; Q84M92; -.
DR ProteomicsDB; 246979; -.
DR EnsemblPlants; AT1G18450.1; AT1G18450.1; AT1G18450.
DR GeneID; 838425; -.
DR Gramene; AT1G18450.1; AT1G18450.1; AT1G18450.
DR KEGG; ath:AT1G18450; -.
DR Araport; AT1G18450; -.
DR TAIR; locus:2014104; AT1G18450.
DR eggNOG; KOG0679; Eukaryota.
DR HOGENOM; CLU_027965_6_2_1; -.
DR InParanoid; Q84M92; -.
DR OMA; GIVEKRC; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; Q84M92; -.
DR PRO; PR:Q84M92; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q84M92; baseline and differential.
DR Genevisible; Q84M92; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031011; C:Ino80 complex; IDA:TAIR.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IDA:TAIR.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:TAIR.
DR GO; GO:0006325; P:chromatin organization; TAS:TAIR.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0048574; P:long-day photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0048235; P:pollen sperm cell differentiation; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Chromatin regulator; Cytoplasm; Developmental protein; Nucleus;
KW Reference proteome.
FT CHAIN 1..441
FT /note="Actin-related protein 4"
FT /id="PRO_0000320528"
FT REGION 48..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1
FT /note="M -> MG (in Ref. 1; AAM53244)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="S -> G (in Ref. 6; AAM65324)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="E -> D (in Ref. 6; AAM65324)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 48937 MW; 04F3FF5732303E7E CRC64;
MYGGDEVSAI VVDLGSHTCK AGYAGEDAPK AVFPSVIGAV DGVEAMDVDV DSTKTNSNSE
DSKTESEKEK SKRKLYVGSQ AMSYRRDHME VLSPIKDGIV SDWDLVDNIW EHAFKSCLMI
DPTEHPMLLA EPPLNTQQQR EKAAELMFEK YKVPALFMAK NPVLTSFATG RATSLVVDCG
GGSTTISPVH DGYVLQKAVV SSPLGGEFLT DCLLKSLESK GIKIRPRYSF KRKEVRAGEF
QVEDVDIPDT TESYKLFCQR MIVGDIKDSI CRVPDTPYDD KSYSNIPTTS YELPDGQTLE
IGADRFKVPD VMFNPSIVQT IPGMEKYAEM IPSVRGLPHM VMESINKCDV DIRRELYSSI
LLAGGTSSMQ QLKERLEKDL IEESPHSARV KVLASGNTTE RRFSVWIGGS ILASLGSFQQ
MWFSKSEYEE HGASYIQRKC P
