ARP4_ASHGO
ID ARP4_ASHGO Reviewed; 479 AA.
AC Q754G5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Actin-related protein 4;
DE AltName: Full=Actin-like protein ARP4;
DE Short=Actin-like protein 4;
GN Name=ARP4; OrderedLocusNames=AFR105C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Chromatin interaction component of the NuA4 histone
CC acetyltransferase complex which is involved in transcriptional
CC activation of selected genes principally by acetylation of nucleosomal
CC histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is
CC required for NuA4 complex integrity. Component of the SWR1 complex
CC which mediates the ATP-dependent exchange of histone H2A for the H2A
CC variant HZT1 leading to transcriptional regulation of selected genes by
CC chromatin remodeling. Component of the INO80 complex which remodels
CC chromatin by shifting nucleosomes and is involved in DNA repair (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex, of
CC the INO80 chromatin remodeling complex, and of the SWR1 chromatin
CC remodeling complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
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DR EMBL; AE016819; AAS53476.1; -; Genomic_DNA.
DR RefSeq; NP_985652.1; NM_211006.1.
DR AlphaFoldDB; Q754G5; -.
DR SMR; Q754G5; -.
DR STRING; 33169.AAS53476; -.
DR EnsemblFungi; AAS53476; AAS53476; AGOS_AFR105C.
DR GeneID; 4621895; -.
DR KEGG; ago:AGOS_AFR105C; -.
DR eggNOG; KOG0679; Eukaryota.
DR HOGENOM; CLU_027965_6_2_1; -.
DR InParanoid; Q754G5; -.
DR OMA; GIVEKRC; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0031011; C:Ino80 complex; IEA:EnsemblFungi.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0051382; P:kinetochore assembly; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..479
FT /note="Actin-related protein 4"
FT /id="PRO_0000089091"
FT REGION 320..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 53866 MW; E8C10989B46DACFB CRC64;
MSNSALQVYG GDEITAVVID PGSFTTNIGY SGTDCPQAIL PSCYGKYTEG EKDELFSEQS
IGLPRKDYEI HNIVQNGEVV DWEKAEKQWD WAIRSELRFE TNSGMPALLT EPIWNSEENR
KKSLEVLLES MDFSACYLVP TATAVSFAMG RPTCLVVDIG HDVTSVCPVV DGMTLSKSSM
RSYIAGSLLN ELIRSQLAPR KVIPLFQVAQ RRPVFMERKF DYEIHPSLQK FVNERQFFQE
FKETMLQVAP TSISKFKSEI ETTSKRSIEA PWGEELVYDS LQRLEFAEQL FTPDLSQFPE
DWPISKDGVV ETWHNDYVPL KRNKPGTNVK DKEGTLDATP VPDENSVTSA DQPNDNGKRN
LEETTPDQKN EVSGLADLIY SSIMSTDVDL RTTLSHNVVI TGGTSSLPGL MDRISAELNR
SLPALKFRML TSGQLRERQY QGWLGGSILA SLGTFHQLWV GKQEYAEVGA DRLLKDRFR