NUOM_RICPR
ID NUOM_RICPR Reviewed; 491 AA.
AC Q9ZCG0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=NADH-quinone oxidoreductase subunit M;
DE EC=7.1.1.-;
DE AltName: Full=NADH dehydrogenase I subunit M;
DE AltName: Full=NDH-1 subunit M;
GN Name=nuoM; OrderedLocusNames=RP793;
OS Rickettsia prowazekii (strain Madrid E).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=272947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC (Fe-S) centers, to quinones in the respiratory chain. Couples the redox
CC reaction to proton translocation (for every two electrons transferred,
CC four hydrogen ions are translocated across the cytoplasmic membrane),
CC and thus conserves the redox energy in a proton gradient (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; AJ235273; CAA15219.1; -; Genomic_DNA.
DR PIR; C71640; C71640.
DR RefSeq; NP_221143.1; NC_000963.1.
DR RefSeq; WP_010886373.1; NC_000963.1.
DR AlphaFoldDB; Q9ZCG0; -.
DR SMR; Q9ZCG0; -.
DR STRING; 272947.RP793; -.
DR EnsemblBacteria; CAA15219; CAA15219; CAA15219.
DR GeneID; 57569915; -.
DR KEGG; rpr:RP793; -.
DR PATRIC; fig|272947.5.peg.829; -.
DR eggNOG; COG1008; Bacteria.
DR HOGENOM; CLU_007100_4_4_5; -.
DR OMA; ITRWGNQ; -.
DR Proteomes; UP000002480; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; NAD; Quinone; Reference proteome; Translocase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..491
FT /note="NADH-quinone oxidoreductase subunit M"
FT /id="PRO_0000118047"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 491 AA; 55260 MW; 55C38A584CA74FF3 CRC64;
MLELPIISIT IFLPLISVLY ILLFFNQNKK ADKLSIYVAM LSSVLTFIST IYILIEFDVS
NNTYQFVERY TWLDKIGLEF HVGVDGIAIF FVVLTSFLTL ICIIGSLFTI KKYIKEYLVC
FLLMESLCIG AFTSINLLLF YLFFEAILVP MYIIIGVWGG DNRIYAALKF FLYTFFGSVF
FLLALIYIYS KIHSFDLTNI LELIGNIPLF AQKILWWAIF IAFAIKTPMI PFHTWLPDAH
VQAPTTGSVI LAGILLKLGG YGFLRVLLPL FPNASQEFAI YVIYLSVIAI IYASLVALAQ
KDIKQMIAYS SIAHMGYVTI GIFSFTEIGI SGAIFQMLSH GIISSSLFLI VGTLYERLHT
KEIAKYGGVA NKMPILATFF MIAMLSSIGL PSTSGFIGEF LSLLGIYKVN VVTAFIAALG
IILGAVYMLK LYKEVMLGEI TNTEIKHFRD LYKYEIISIA PLILLIIYFG LMPNSILNVF
HLSVENLLIK F