ID   ARP4_NEUCR              Reviewed;         469 AA.
AC   Q7SHR0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Actin-related protein 4;
DE   AltName: Full=Actin-like protein 4;
GN   Name=arp-4; ORFNames=NCU02555;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Chromatin interaction component of the NuA4 histone
CC       acetyltransferase complex which is involved in transcriptional
CC       activation of selected genes principally by acetylation of nucleosomal
CC       histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is
CC       required for NuA4 complex integrity. Component of the SWR1 complex
CC       which mediates the ATP-dependent exchange of histone H2A for the H2A
CC       variant H2A.Z leading to transcriptional regulation of selected genes
CC       by chromatin remodeling. Component of the INO80 complex which remodels
CC       chromatin by shifting nucleosomes and is involved in DNA repair (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex, of
CC       the INO80 chromatin remodeling complex, and of the SWR1 chromatin
CC       remodeling complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
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DR   EMBL; CM002236; EAA36450.2; -; Genomic_DNA.
DR   RefSeq; XP_965686.2; XM_960593.3.
DR   AlphaFoldDB; Q7SHR0; -.
DR   SMR; Q7SHR0; -.
DR   STRING; 5141.EFNCRP00000002099; -.
DR   EnsemblFungi; EAA36450; EAA36450; NCU02555.
DR   GeneID; 3881836; -.
DR   KEGG; ncr:NCU02555; -.
DR   VEuPathDB; FungiDB:NCU02555; -.
DR   HOGENOM; CLU_027965_6_2_1; -.
DR   InParanoid; Q7SHR0; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0031011; C:Ino80 complex; IEA:EnsemblFungi.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00432; ACTINS_2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..469
FT                   /note="Actin-related protein 4"
FT                   /id="PRO_0000089099"
FT   REGION          104..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  51986 MW;  899E8A36F030566B CRC64;
     MSHQQPLSSS VQPTDIYGGD EVSALVLDPG YCNTRAGYAG EEMPKQVLPS FYGHINGRDV
     FGDEYIVPKP GFEVRNYMNR DSVVEDWDAA TRMWEHVLVK RLQPERSTPP SKKGINISDD
     GDVPMEDDGN NNEDATDALE KPLAENPLLM TEAPWNSPKA REKAIEISME TWGVPAFWLS
     KTPVLAAFAA GKATALVIDV GGANTSVTAI HDGMVLKRSI QRSPVGGVWL SSQICKMWDG
     SEPKVDVVPR FMVESKKPVE AGAPAEANLR KFNFDIHPSF RAYEEERVLT EFKESVVEVW
     RGPQRFTTPG NEDAVRTQPG RVFEMPDGSN QMWREQRFKV SEGMWDETAA YNSTDEEGRV
     TKAQTIPALI KAALEGVDVD LRPNILGNVV VTGSTSLLNG FNDRLNHELA QMYPGVKIKI
     HAAGLTTERR FGAWIGGSIL ASLGTFHQMW ISRKEYDENG AGIVEKRCK