ID   ARP4_STRPY              Reviewed;         386 AA.
AC   P13050;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=IgA receptor;
DE   Flags: Precursor;
GN   Name=arp4;
OS   Streptococcus pyogenes.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AW43 / Serotype M60;
RX   PubMed=2691841; DOI=10.1111/j.1365-2958.1989.tb00261.x;
RA   Frithz E., Heden L.-O., Lindahl G.;
RT   "Extensive sequence homology between IgA receptor and M proteins in
RT   Streptococcus pyogenes.";
RL   Mol. Microbiol. 3:1111-1119(1989).
CC   -!- FUNCTION: Binds IgA of both subclasses, and also binds polyclonal IgG
CC       weakly.
CC   -!- INTERACTION:
CC       P13050; P04003: C4BPA; Xeno; NbExp=5; IntAct=EBI-978341, EBI-978348;
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- SIMILARITY: Belongs to the M protein family. {ECO:0000305}.
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DR   EMBL; X15198; CAA33269.1; -; Genomic_DNA.
DR   PIR; S05568; S05568.
DR   AlphaFoldDB; P13050; -.
DR   SMR; P13050; -.
DR   IntAct; P13050; 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR019950; M_anchor.
DR   InterPro; IPR003345; M_repeat.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF02370; M; 3.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   PRINTS; PR00015; GPOSANCHOR.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Peptidoglycan-anchor; Receptor; Repeat; Secreted; Signal.
FT   SIGNAL          1..41
FT   CHAIN           42..356
FT                   /note="IgA receptor"
FT                   /id="PRO_0000005591"
FT   PROPEP          357..386
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005592"
FT   REPEAT          153..187
FT                   /note="C-1"
FT   REPEAT          188..229
FT                   /note="C-2"
FT   REPEAT          230..271
FT                   /note="C-3"
FT   REGION          42..152
FT                   /note="IgA-binding"
FT                   /evidence="ECO:0000255"
FT   REGION          79..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..271
FT                   /note="3 X tandem repeats"
FT   REGION          233..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           353..357
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        79..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         356
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   386 AA;  43837 MW;  C5FBDCDBB97BA0B8 CRC64;
     MARKDTNKQY SLRKLKTGTA SVAVAVAVLG AGFANQTEVK AAEIKKPQAD SAWNWPKEYN
     ALLKENEELK VEREKYLSYA DDKEKDPQYR ALMGENQDLR KREGQYQDKI EELEKERKEK
     QERQEQLERQ YQIEADKHYQ EQQKKHQQEQ QQLEAEKQKL AKDKQISDAS RQGLSRDLEA
     SRAAKKELEA EHQKLKEEKQ ISDASRQGLS RDLEASREAK KKVEADLAAL TAEHQKLKED
     KQISDASRQG LSRDLEASRE AKKKVEADLA EANSKLQALE KLNKELEEGK KLSEKEKAEL
     QARLEAEAKA LKEQLAKQAE ELAKLKGNQT PNAKVAPQAN RSRSAMTQQK RTLPSTGETA
     NPFFTAAAAT VMVSAGMLAL KRKEEN