ID   ARP4_YARLI              Reviewed;         432 AA.
AC   Q6C061;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Actin-related protein 4;
DE   AltName: Full=Actin-like protein ARP4;
DE            Short=Actin-like protein 4;
GN   Name=ARP4; OrderedLocusNames=YALI0F27533g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Chromatin interaction component of the NuA4 histone
CC       acetyltransferase complex which is involved in transcriptional
CC       activation of selected genes principally by acetylation of nucleosomal
CC       histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is
CC       required for NuA4 complex integrity. Component of the SWR1 complex
CC       which mediates the ATP-dependent exchange of histone H2A for the H2A
CC       variant HZT1 leading to transcriptional regulation of selected genes by
CC       chromatin remodeling. Component of the INO80 complex which remodels
CC       chromatin by shifting nucleosomes and is involved in DNA repair (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex, of
CC       the INO80 chromatin remodeling complex, and of the SWR1 chromatin
CC       remodeling complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78763.1; -; Genomic_DNA.
DR   RefSeq; XP_505951.1; XM_505951.1.
DR   AlphaFoldDB; Q6C061; -.
DR   SMR; Q6C061; -.
DR   STRING; 4952.CAG78763; -.
DR   EnsemblFungi; CAG78763; CAG78763; YALI0_F27533g.
DR   GeneID; 2909050; -.
DR   KEGG; yli:YALI0F27533g; -.
DR   VEuPathDB; FungiDB:YALI0_F27533g; -.
DR   HOGENOM; CLU_027965_6_2_1; -.
DR   InParanoid; Q6C061; -.
DR   OMA; GIVEKRC; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..432
FT                   /note="Actin-related protein 4"
FT                   /id="PRO_0000089102"
SQ   SEQUENCE   432 AA;  47043 MW;  7CB471FF20DC0CC5 CRC64;
     MTTTAPAPQV YGGDEVATLV IDTGSSYTRV GYAGEDTPKL VVSTECGLMA DEDVEMEDDT
     SNTTKKLNKY KVGDSANLPL PNMEVLHPLT DGIVADWDAV QNIWEYSLAR LNADTKTHPL
     MLTEPCWNTQ ANKLKALEIA FESLEVPASY LVKDAVASAF AAGKGNALVL DVGSEVASVT
     PVIDGLVLYK PARRSQYAGD YLDRQIKKVL VSRGIDLTPR FEIKNKKAVE MGEPPVFTKR
     ELPNVTHSFT DLQVSRILSE FKDSMCQVND VPLTPEISGE AADRVFEFPT GYSTTFGADR
     LSTSESLFKP SEYPFDGETV PDTARGLSEM VVDTINASNV DVRAHLANNI VITGGGSLVQ
     GLSDRVSKDV TQALSGLKVR VAAASNQEER RHGAWIGGSV LGSLGSFHQL WVSKQEWQEK
     GGDYLVEKKR FK