ID   ARP5L_MOUSE             Reviewed;         153 AA.
AC   Q9D898;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 5-like protein;
DE   AltName: Full=Arp2/3 complex 16 kDa subunit 2;
DE            Short=ARC16-2;
GN   Name=Arpc5l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Small intestine;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 90-102, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Hippocampus;
RA   Lubec G., Klug S.;
RL   Submitted (MAR-2007) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May function as component of the Arp2/3 complex which is
CC       involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks. {ECO:0000250}.
CC   -!- SUBUNIT: May be a component of the Arp2/3 complex in which it may
CC       replace ARPC5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC5 family. {ECO:0000305}.
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DR   EMBL; AK008255; BAB25561.1; -; mRNA.
DR   EMBL; BC024482; AAH24482.1; -; mRNA.
DR   CCDS; CCDS38120.1; -.
DR   RefSeq; NP_083085.1; NM_028809.1.
DR   AlphaFoldDB; Q9D898; -.
DR   SMR; Q9D898; -.
DR   BioGRID; 216564; 9.
DR   IntAct; Q9D898; 3.
DR   MINT; Q9D898; -.
DR   STRING; 10090.ENSMUSP00000108483; -.
DR   iPTMnet; Q9D898; -.
DR   PhosphoSitePlus; Q9D898; -.
DR   REPRODUCTION-2DPAGE; Q9D898; -.
DR   EPD; Q9D898; -.
DR   jPOST; Q9D898; -.
DR   MaxQB; Q9D898; -.
DR   PaxDb; Q9D898; -.
DR   PRIDE; Q9D898; -.
DR   ProteomicsDB; 281832; -.
DR   TopDownProteomics; Q9D898; -.
DR   Antibodypedia; 16361; 66 antibodies from 19 providers.
DR   DNASU; 74192; -.
DR   Ensembl; ENSMUST00000112862; ENSMUSP00000108483; ENSMUSG00000026755.
DR   GeneID; 74192; -.
DR   KEGG; mmu:74192; -.
DR   UCSC; uc008joa.1; mouse.
DR   CTD; 81873; -.
DR   MGI; MGI:1921442; Arpc5l.
DR   VEuPathDB; HostDB:ENSMUSG00000026755; -.
DR   eggNOG; KOG3380; Eukaryota.
DR   GeneTree; ENSGT00940000158501; -.
DR   HOGENOM; CLU_101888_1_1_1; -.
DR   InParanoid; Q9D898; -.
DR   OMA; SQIQGRN; -.
DR   OrthoDB; 1565115at2759; -.
DR   BioGRID-ORCS; 74192; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Arpc5l; mouse.
DR   PRO; PR:Q9D898; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q9D898; protein.
DR   Bgee; ENSMUSG00000026755; Expressed in interventricular septum and 261 other tissues.
DR   ExpressionAtlas; Q9D898; baseline and differential.
DR   Genevisible; Q9D898; MM.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR   GO; GO:0045202; C:synapse; IDA:SynGO.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.25.40.190; -; 1.
DR   InterPro; IPR006789; ARPC5.
DR   InterPro; IPR036743; ARPC5_sf.
DR   InterPro; IPR030075; ARPC5L.
DR   PANTHER; PTHR12644; PTHR12644; 1.
DR   PANTHER; PTHR12644:SF2; PTHR12644:SF2; 1.
DR   Pfam; PF04699; P16-Arc; 1.
DR   PIRSF; PIRSF039096; p16-ARC; 1.
DR   SUPFAM; SSF69103; SSF69103; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..153
FT                   /note="Actin-related protein 2/3 complex subunit 5-like
FT                   protein"
FT                   /id="PRO_0000279481"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BPX5"
SQ   SEQUENCE   153 AA;  16980 MW;  F01A86DC009ECEC1 CRC64;
     MARNTLSSRF RRVDIDEFDE NKFVDEHEEA AAAAGEPGPD PCEVDGLLRQ GDMLRAFHAA
     LRNSPINTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL DRNGIDLLMK YIYKGFEKPT
     ENSSAVLLQW HEKALAVGGL GSIIRVLTAR KTV