ID   ARP5_DICDI              Reviewed;         684 AA.
AC   Q54E71;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Actin-related protein 5;
DE   AltName: Full=Actin-related protein E;
GN   Name=arpE; Synonyms=actr5; ORFNames=DDB_G0291728;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Proposed core component of the chromatin remodeling Ino80
CC       complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the chromatin-remodeling Ino80 complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP5 subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000182; EAL61560.1; -; Genomic_DNA.
DR   RefSeq; XP_629991.1; XM_629989.1.
DR   AlphaFoldDB; Q54E71; -.
DR   STRING; 44689.DDB0234009; -.
DR   PaxDb; Q54E71; -.
DR   EnsemblProtists; EAL61560; EAL61560; DDB_G0291728.
DR   GeneID; 8628321; -.
DR   KEGG; ddi:DDB_G0291728; -.
DR   dictyBase; DDB_G0291728; arpE.
DR   eggNOG; KOG0681; Eukaryota.
DR   HOGENOM; CLU_008246_1_0_1; -.
DR   InParanoid; Q54E71; -.
DR   OMA; TNWNHQE; -.
DR   PhylomeDB; Q54E71; -.
DR   PRO; PR:Q54E71; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031011; C:Ino80 complex; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR027664; Arp5.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF16; PTHR11937:SF16; 1.
DR   Pfam; PF00022; Actin; 2.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Coiled coil; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..684
FT                   /note="Actin-related protein 5"
FT                   /id="PRO_0000328716"
FT   REGION          392..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          262..469
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   684 AA;  79390 MW;  E15863B26A376741 CRC64;
     MNNIFAYKEI ESPIDDQICK DYKTKYANPS IPIIIDNGSY QCRAGFANDI SPKLIFRSLV
     GKVKSTSSPI VGNSLKEGDI SRLTIKSPFD SNLLVHPPSQ ESIFDYIFHK FGIENEIENP
     VLITEPTSNP TFCRKYMSEL LFECYNIKSV VYGIDSLFSF YGQRDQFKDG GKNSLIIGSS
     FNTTHIYNVQ NYNVSHQQTK RINIGGGAST DYLRKLIHLK YPKHKSYFTQ NYTNKIKEEH
     CYVSQGQYIE ELKEFENDQL AKEKSVIIQL PYQEIDFEKL EEERQRKIQN RKDLGAKLRE
     LADKKRLEKK TELEDKLASL ESILALKTTN VEEFQQTLKS KSYATEKDLI RDIDDLKDKL
     FGKKKESEQV EDTEEFPLLF IADSELNADQ LKEKKKQRQL KSMKDGRLAQ KRKRDEEKEK
     EKEKEEERDR QEEESFLKDP EHYLKDLHSR KSKILEKREA RQKQKQKANI VQRNSRLRTI
     VNPTNHGNYG EKGEEVEDPE EAEESREMAI LDKLLNKFDP TSISSAIVSH DDQFPIGEYH
     TAEDFQVSLG VERIKCPETL FQPKAIIGVD QMGLVEAIIS SILSQLPVDT RKLVTENIFL
     TGGNVNTKHF KDRIHYEIQQ IREPYSPLTI LKSKDSQLDA WLGARKWCLD NQDNWSNVSI
     SKQDYQEKGY DYIKSHFASN LSLN