NUP35_DANRE
ID NUP35_DANRE Reviewed; 308 AA.
AC Q6P6X9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Nucleoporin NUP35 {ECO:0000250|UniProtKB:Q8NFH5};
DE AltName: Full=35 kDa nucleoporin;
DE AltName: Full=Nuclear pore complex protein Nup53;
DE AltName: Full=Nucleoporin NUP53 {ECO:0000250|UniProtKB:Q8NFH5};
GN Name=nup35; Synonyms=nup53; ORFNames=zgc:65979;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54 AND SER-61, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q8NFH5}.
CC -!- SIMILARITY: Belongs to the Nup35 family. {ECO:0000305}.
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DR EMBL; BC061958; AAH61958.1; -; mRNA.
DR RefSeq; NP_956360.1; NM_200066.1.
DR AlphaFoldDB; Q6P6X9; -.
DR SMR; Q6P6X9; -.
DR STRING; 7955.ENSDARP00000033355; -.
DR iPTMnet; Q6P6X9; -.
DR PaxDb; Q6P6X9; -.
DR Ensembl; ENSDART00000032344; ENSDARP00000033355; ENSDARG00000012222.
DR GeneID; 337461; -.
DR KEGG; dre:337461; -.
DR CTD; 129401; -.
DR ZFIN; ZDB-GENE-030131-9407; nup35.
DR eggNOG; KOG4285; Eukaryota.
DR GeneTree; ENSGT00390000005923; -.
DR HOGENOM; CLU_056189_0_0_1; -.
DR InParanoid; Q6P6X9; -.
DR OMA; FWVTIFG; -.
DR OrthoDB; 1163548at2759; -.
DR PhylomeDB; Q6P6X9; -.
DR TreeFam; TF325369; -.
DR Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DRE-191859; snRNP Assembly.
DR Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DRE-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:Q6P6X9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000012222; Expressed in early embryo and 28 other tissues.
DR ExpressionAtlas; Q6P6X9; baseline.
DR GO; GO:0031965; C:nuclear membrane; IEA:InterPro.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0044615; C:nuclear pore nuclear basket; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR017389; Nucleoporin_NUP53.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR007846; RRM_NUP35_dom.
DR PANTHER; PTHR21527; PTHR21527; 1.
DR Pfam; PF05172; Nup35_RRM; 1.
DR PIRSF; PIRSF038119; Nucleoporin_NUP53; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS51472; RRM_NUP35; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..308
FT /note="Nucleoporin NUP35"
FT /id="PRO_0000234297"
FT DOMAIN 155..235
FT /note="RRM Nup35-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00804"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
SQ SEQUENCE 308 AA; 32885 MW; 7A6405437D96F849 CRC64;
MEIQSCIEPM TLGSPTSPKP GAQFLPGFLM GDLPAPVTPQ PRSFGLTGGA EIRSPLLAGG
SPPQPVVPTP KDKSGAPPVR SIYDDLNGSA VGMSPLAARK QPFAGVHTPL SGLQGTPGTV
SNFFSPVSQQ RKTTLSPAQV DPFFTQGDAL SSEDQLDDTW ITVFGFPPAS ASYILLQFAQ
YGNILKHVMS NTGNWMHVQY QSKLQARKAL SKDGKIFGEA IMIGVKPCID KSVMESLDKG
STSSSVFTPP VKAPCTPSHP LSTPRSVMRP LSAAYKASSS DYQVVSDQQT PKKDESFVSK
AMEYMFGW
