ID   ARP5_DROPS              Reviewed;         651 AA.
AC   Q293V2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Actin-related protein 5;
GN   Name=Arp5 {ECO:0000250|UniProtKB:Q9VEC3}; ORFNames=GA20705;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Proposed core component of the chromatin remodeling Ino80
CC       complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the chromatin remodeling Ino80 complex.
CC       {ECO:0000250|UniProtKB:Q9VEC3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEC3}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP5 subfamily. {ECO:0000305}.
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DR   EMBL; CM000070; EAL29112.2; -; Genomic_DNA.
DR   RefSeq; XP_001359960.2; XM_001359923.4.
DR   AlphaFoldDB; Q293V2; -.
DR   STRING; 7237.FBpp0284893; -.
DR   EnsemblMetazoa; FBtr0286455; FBpp0284893; FBgn0080696.
DR   GeneID; 4803177; -.
DR   KEGG; dpo:Dpse_GA20705; -.
DR   eggNOG; KOG0681; Eukaryota.
DR   HOGENOM; CLU_008246_1_0_1; -.
DR   InParanoid; Q293V2; -.
DR   OMA; TNWNHQE; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0080696; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0031011; C:Ino80 complex; IEA:EnsemblMetazoa.
DR   GO; GO:0006338; P:chromatin remodeling; ISS:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR027664; Arp5.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF16; PTHR11937:SF16; 1.
DR   Pfam; PF00022; Actin; 2.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Coiled coil; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..651
FT                   /note="Actin-related protein 5"
FT                   /id="PRO_0000307118"
FT   REGION          362..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          394..418
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        362..383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  75539 MW;  F47E7EAD3B6422AB CRC64;
     MGSPKRVLVI DNGSYECRVG WNNTKEPALR FRNVLTKPRK DRKKEAIPDT TDGAPTPVAA
     EVPAEIQVGN DITNIEAVRA HLKSPFERNI ITNWNHQEQI FDYIFTKMGF EGEQSIANPI
     VLTEALANPN FCRQNMSELL FECYGIPAVS YGIDALYSWE HYQNRRKKVS DALIISLGYS
     TTHVIPVLNG KLQLQHVRRL NVGGYHIITY LLCLMQMKYP VHLNAISISR MEKLVHEHCH
     IAVDYREELL KWGQMDYYEE HIMKIQLPYN PVTATNALLT AEQKLEKRRE LAMRLLEIKN
     RREGEKLLED EQQLFVYNKL RQLYEQDKLQ KFELALAQQQ IGNLDELDSL ISTISNRIKR
     IKERPLSSPK PSKQQEKIDK MPKAPEGVSQ ADWLAELQSK REQLLQRKQT RQQQRQEQGK
     RHTHAAQERM RIISTLARSE KRRKANGEEE DDGFGMNDND WDVYKRINRY NDDSDSDADN
     EQLLEFEKIL SHYDVNFDDG NAVQTQSAAE NYQLHFGVED IRVPEILFQP SMIGSPEAGL
     AELIAFVLKL FTAQEQQRMV EHVYLTGGCA QFRGLKERLA REFLEMRPFQ SKFSIYESDD
     HTLSAWLGAC VQASQPNFGQ TLTTRKDYQE HGSEYFREHR ASNLFYPTPK D