ID   NUP35_XENTR             Reviewed;         330 AA.
AC   Q66IJ0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Nucleoporin NUP35 {ECO:0000250|UniProtKB:Q8NFH5};
DE   AltName: Full=35 kDa nucleoporin;
DE   AltName: Full=Nuclear pore complex protein Nup53;
DE   AltName: Full=Nucleoporin NUP53 {ECO:0000250|UniProtKB:Q8NFH5};
GN   Name=nup35; Synonyms=nup53;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q8NFH5}.
CC   -!- SIMILARITY: Belongs to the Nup35 family. {ECO:0000305}.
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DR   EMBL; BC081329; AAH81329.1; -; mRNA.
DR   RefSeq; NP_001008124.1; NM_001008123.1.
DR   AlphaFoldDB; Q66IJ0; -.
DR   SMR; Q66IJ0; -.
DR   DNASU; 493486; -.
DR   GeneID; 493486; -.
DR   KEGG; xtr:493486; -.
DR   CTD; 129401; -.
DR   Xenbase; XB-GENE-980941; nup35.
DR   InParanoid; Q66IJ0; -.
DR   OrthoDB; 1163548at2759; -.
DR   Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031965; C:nuclear membrane; IEA:InterPro.
DR   GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR   GO; GO:0044615; C:nuclear pore nuclear basket; IBA:GO_Central.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR017389; Nucleoporin_NUP53.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR007846; RRM_NUP35_dom.
DR   PANTHER; PTHR21527; PTHR21527; 1.
DR   Pfam; PF05172; Nup35_RRM; 1.
DR   PIRSF; PIRSF038119; Nucleoporin_NUP53; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS51472; RRM_NUP35; 1.
PE   2: Evidence at transcript level;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..330
FT                   /note="Nucleoporin NUP35"
FT                   /id="PRO_0000234298"
FT   DOMAIN          173..253
FT                   /note="RRM Nup35-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00804"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  35227 MW;  28C534E23D3A9F77 CRC64;
     MAAFSMEPMG AEPMALGSPT SPKPSAGAQF LPGFLLGDIP TPVTPQQRPS IGVMEMRSPL
     LSGGSPPQPV VPTHKDKSGA PPVRSIYDDI ASPGLGSTPL NPRKTASFSV LHTPLSGVIP
     SSPECKNISG SRKRPASSVF SPATIGHSRK TTLSPAQMDP FYTQGDALTS DDQLDDTWVT
     VFGFPQASAS YILLQFAQYG NIIKHVMSNN GNWMHIQYQS KLQARKALSK DGRIFGESIM
     IGVKPCIDKS VMEATEKVST PTVSSVFTPP VKNIGTPTQS VGTPRAASMR PLAATYKTPA
     SADYQVVADK QAPRKDESIV SKAMEYMFGW