NUP37_CHATD
ID NUP37_CHATD Reviewed; 751 AA.
AC G0S2X1; G0ZGV1;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Nucleoporin NUP37 {ECO:0000303|PubMed:21784248};
DE AltName: Full=Nuclear pore protein NUP37;
GN Name=NUP37; ORFNames=CTHT_0018790;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SUBUNIT: The nuclear pore complex (NPC) constitutes the exclusive means
CC of nucleocytoplasmic transport. NPCs allow the passive diffusion of
CC ions and small molecules and the active, nuclear transport receptor-
CC mediated bidirectional transport of macromolecules such as proteins,
CC RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the
CC nuclear envelope. The 55-60 MDa NPC is composed of at least 28
CC different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1,
CC NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49,
CC NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13
CC and SEH1. Due to its 8-fold rotational symmetry, all subunits are
CC present with 8 copies or multiples thereof.
CC {ECO:0000250|UniProtKB:Q8NFH4, ECO:0000305|PubMed:21784248}.
CC -!- INTERACTION:
CC G0S2X1; G0S0E7: NUP120; NbExp=8; IntAct=EBI-16069375, EBI-16069242;
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q8NFH4}.
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DR EMBL; GL988040; EGS22354.1; -; Genomic_DNA.
DR EMBL; JF276295; AEL00689.1; -; Genomic_DNA.
DR RefSeq; XP_006692373.1; XM_006692310.1.
DR AlphaFoldDB; G0S2X1; -.
DR DIP; DIP-60571N; -.
DR IntAct; G0S2X1; 3.
DR STRING; 759272.G0S2X1; -.
DR TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR EnsemblFungi; EGS22354; EGS22354; CTHT_0018790.
DR GeneID; 18255917; -.
DR KEGG; cthr:CTHT_0018790; -.
DR eggNOG; ENOG502SJ54; Eukaryota.
DR HOGENOM; CLU_007901_0_0_1; -.
DR OrthoDB; 395790at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW WD repeat.
FT CHAIN 1..751
FT /note="Nucleoporin NUP37"
FT /id="PRO_0000433191"
FT REPEAT 21..65
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 162..209
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 237..271
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 282..322
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 351..390
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 455..492
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 494..534
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 57..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 716..750
FT /evidence="ECO:0000255"
FT COMPBIAS 63..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 742..751
FT /note="GRKRVFFEEG -> AELGKDCGKSSLFGKQKVAPAEVHSPRGGSRAREMREL
FT LRLKPEELLDSPKMEKVKERITISPAKRKASGGLLREVLERSAKRNPALFPEKF (in
FT Ref. 1; EGS22354)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 751 AA; 80253 MW; 812400069D09F2DE CRC64;
MALQPVPRMR RTLQNTQHTY SLGRRIYDVK TYPVQSPQGA TILIYGHENG ATVVWRGGRR
LKPPKPQTNE KRNGTKPEDA VMIIDSDDET GPTFVDKPEF EDSPSVADGS VAEIIQTLDL
ALGTAVNHIA VLPMPPCAAE DASWNGANIL KTKIVFAVTC ATNDVYVITL PLTPPSHEAK
ARPELRKSLL AGNAGKGVWG ETLTLLTGPS RSCNGVAISL VKHRSSSRSR SSERSAAQAA
PITRVVVAAH SREASGTLRL WDVPLEAKPG TINRVEPFQT EYLPSPLTSI SFNPVNLTQL
LTVASPHAVR IYDYATASLP SDDTSEGPFP SQGSWLISLY PPFARGPAMS TSRKPIVAAE
WIARGRAILT LLADGQWGIW DLDGASPTAA GGGSNLFSKT SAGLRGTAIT AFSVTGHLEG
TSPLRNPTTQ KASSSSSGEF VPMTPHTRRD AIATAFGGSP EKLAAVRGGI TVAQLPSTLT
SGAGDESAVL FLGGADPIVC VIPVLSKFWD SQLRRAAGGG VNLWSGAQPT RMIRLTDLSA
GLLGERCTGA VAITKAVRAN ASTNGILKED DNSGSQGLPI EVLLQGESRL VIVHENGDAP
TSSLTSRLLG ARKKQRDEFK SVNAIVAYPP LEKPSVSFNL NLTQRPEKPG TLFAPRSRHS
KSLFEQSIDT IPSTDAGDEE TIPATSAPSS QQGFMFATDL ELAADLPDDE ADAEGRDVEQ
ELLDIMEIDR ELEQLEQARE RGRKRVFFEE G
