NUP37_DROME
ID NUP37_DROME Reviewed; 320 AA.
AC Q9VBU8;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Nucleoporin Nup37 {ECO:0000305};
DE AltName: Full=37 kDa nucleoporin {ECO:0000305};
GN Name=Nup37 {ECO:0000312|FlyBase:FBgn0039301};
GN ORFNames=CG11875 {ECO:0000312|FlyBase:FBgn0039301};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAS77422.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAS77422.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAS77422.1};
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION (MICROBIAL INFECTION), AND DISRUPTION PHENOTYPE (MICROBIAL
RP INFECTION).
RX PubMed=22851751; DOI=10.1128/iai.00670-12;
RA Von Ohlen T., Luce-Fedrow A., Ortega M.T., Ganta R.R., Chapes S.K.;
RT "Identification of critical host mitochondrion-associated genes during
RT Ehrlichia chaffeensis infections.";
RL Infect. Immun. 80:3576-3586(2012).
CC -!- FUNCTION: As part of the nuclear pore complex (NPC), has a role in its
CC assembly and function. {ECO:0000250|UniProtKB:Q8NFH4}.
CC -!- FUNCTION: (Microbial infection) Required for optimal replication of
CC E.chaffeensis. {ECO:0000269|PubMed:22851751}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q8NFH4}.
CC -!- DISRUPTION PHENOTYPE: (Microbial infection) After infection with
CC E.chaffeensis, results in reduced bacterial replication rate and
CC increased survival. {ECO:0000269|PubMed:22851751}.
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DR EMBL; AE014297; AAF56429.1; -; Genomic_DNA.
DR EMBL; AE014297; AGB96330.1; -; Genomic_DNA.
DR EMBL; BT012297; AAS77422.1; -; mRNA.
DR RefSeq; NP_001262950.1; NM_001276021.1.
DR RefSeq; NP_651360.1; NM_143103.4.
DR AlphaFoldDB; Q9VBU8; -.
DR SMR; Q9VBU8; -.
DR STRING; 7227.FBpp0304467; -.
DR PaxDb; Q9VBU8; -.
DR PRIDE; Q9VBU8; -.
DR DNASU; 43040; -.
DR EnsemblMetazoa; FBtr0084812; FBpp0084187; FBgn0039301.
DR EnsemblMetazoa; FBtr0332158; FBpp0304467; FBgn0039301.
DR GeneID; 43040; -.
DR KEGG; dme:Dmel_CG11875; -.
DR UCSC; CG11875-RA; d. melanogaster.
DR CTD; 79023; -.
DR FlyBase; FBgn0039301; Nup37.
DR VEuPathDB; VectorBase:FBgn0039301; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00390000010777; -.
DR HOGENOM; CLU_074370_0_0_1; -.
DR InParanoid; Q9VBU8; -.
DR OMA; GGMAWHQ; -.
DR OrthoDB; 921692at2759; -.
DR PhylomeDB; Q9VBU8; -.
DR Reactome; R-DME-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DME-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DME-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DME-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR BioGRID-ORCS; 43040; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43040; -.
DR PRO; PR:Q9VBU8; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039301; Expressed in secondary oocyte and 20 other tissues.
DR GO; GO:0031080; C:nuclear pore outer ring; ISS:FlyBase.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR037626; NUP37.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22806; PTHR22806; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..320
FT /note="Nucleoporin Nup37"
FT /evidence="ECO:0000305"
FT /id="PRO_0000446160"
FT REPEAT 67..113
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 118..157
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 160..200
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 203..242
FT /note="WD 4"
FT /evidence="ECO:0000255"
SQ SEQUENCE 320 AA; 35350 MW; 4F46CB3401A36A6D CRC64;
MRSVIEPDHS IQLNEAIYCY DICTNDFAYN LIAVAFRKHL SLLLVGLPEE SGEFGYTRLQ
DMDLGEKEQR SVSALAFSPD TSLNCTPNNV TLCAANGSQL KLYRTDLGQF TSLQVLRGHG
DYVNDVSWVC DGELLASVSD DFTCRFWTTT GGGENVITFG LSSAGMSVKS HPEDPNKVLV
AEKKGIIHLY NVTLKQTVIS VESPKFPLMS ADWAHSNRLF ITSLAGGDVV TWDLNRPYVP
ADVKQVHEDC GRVVRFAPGS SEMVIAMVIG LTLKVFAAKS TVPLLEASLK SYGGMAWHQR
LPYISAVSDR KLLFWKVQMK
