NUP37_MOUSE
ID NUP37_MOUSE Reviewed; 326 AA.
AC Q9CWU9; Q9CZ80;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Nucleoporin Nup37;
DE AltName: Full=Nup107-160 subcomplex subunit Nup37;
GN Name=Nup37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore
CC complex (NPC). The Nup107-160 subcomplex is required for the assembly
CC of a functional NPC. The Nup107-160 subcomplex is also required for
CC normal kinetochore microtubule attachment, mitotic progression and
CC chromosome segregation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Nup107-160 subcomplex of the nuclear pore
CC complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133,
CC NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK010370; BAB26888.1; -; mRNA.
DR EMBL; AK012890; BAB28538.1; -; mRNA.
DR EMBL; AK040463; BAC30597.1; -; mRNA.
DR EMBL; AK165537; BAE38243.1; -; mRNA.
DR EMBL; CH466539; EDL21469.1; -; Genomic_DNA.
DR EMBL; CH466539; EDL21470.1; -; Genomic_DNA.
DR EMBL; CH466539; EDL21471.1; -; Genomic_DNA.
DR EMBL; BC011102; AAH11102.1; -; mRNA.
DR EMBL; BC032180; AAH32180.1; -; mRNA.
DR CCDS; CCDS24107.1; -.
DR RefSeq; NP_081467.2; NM_027191.2.
DR RefSeq; NP_082610.1; NM_028334.4.
DR AlphaFoldDB; Q9CWU9; -.
DR SMR; Q9CWU9; -.
DR BioGRID; 213645; 1.
DR ComplexPortal; CPX-4474; Nuclear pore complex.
DR STRING; 10090.ENSMUSP00000129728; -.
DR iPTMnet; Q9CWU9; -.
DR PhosphoSitePlus; Q9CWU9; -.
DR EPD; Q9CWU9; -.
DR MaxQB; Q9CWU9; -.
DR PaxDb; Q9CWU9; -.
DR PeptideAtlas; Q9CWU9; -.
DR PRIDE; Q9CWU9; -.
DR ProteomicsDB; 293781; -.
DR Antibodypedia; 55085; 110 antibodies from 15 providers.
DR DNASU; 69736; -.
DR Ensembl; ENSMUST00000052355; ENSMUSP00000059880; ENSMUSG00000035351.
DR Ensembl; ENSMUST00000169309; ENSMUSP00000129728; ENSMUSG00000035351.
DR GeneID; 69736; -.
DR KEGG; mmu:69736; -.
DR UCSC; uc007gre.2; mouse.
DR CTD; 79023; -.
DR MGI; MGI:1919964; Nup37.
DR VEuPathDB; HostDB:ENSMUSG00000035351; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00390000010777; -.
DR HOGENOM; CLU_074370_0_0_1; -.
DR InParanoid; Q9CWU9; -.
DR OMA; GGMAWHQ; -.
DR OrthoDB; 921692at2759; -.
DR PhylomeDB; Q9CWU9; -.
DR TreeFam; TF325769; -.
DR Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-MMU-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-MMU-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-MMU-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-MMU-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-MMU-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR Reactome; R-MMU-191859; snRNP Assembly.
DR Reactome; R-MMU-2467813; Separation of Sister Chromatids.
DR Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-MMU-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-MMU-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-MMU-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-MMU-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-MMU-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-MMU-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-MMU-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-MMU-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-MMU-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
DR Reactome; R-MMU-68877; Mitotic Prometaphase.
DR Reactome; R-MMU-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
DR BioGRID-ORCS; 69736; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Nup37; mouse.
DR PRO; PR:Q9CWU9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CWU9; protein.
DR Bgee; ENSMUSG00000035351; Expressed in primitive streak and 247 other tissues.
DR ExpressionAtlas; Q9CWU9; baseline and differential.
DR Genevisible; Q9CWU9; MM.
DR GO; GO:0000776; C:kinetochore; ISO:MGI.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0005643; C:nuclear pore; IC:ComplexPortal.
DR GO; GO:0031080; C:nuclear pore outer ring; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IC:ComplexPortal.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR037626; NUP37.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22806; PTHR22806; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW WD repeat.
FT CHAIN 1..326
FT /note="Nucleoporin Nup37"
FT /id="PRO_0000051110"
FT REPEAT 70..117
FT /note="WD 1"
FT REPEAT 122..162
FT /note="WD 2"
FT REPEAT 164..203
FT /note="WD 3"
FT REPEAT 294..325
FT /note="WD 4"
FT CONFLICT 27
FT /note="F -> L (in Ref. 1; BAB26888)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="K -> R (in Ref. 1; BAB26888)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 36732 MW; F620A40BC9E10CE9 CRC64;
MKQDATRNAA YTVDCEDYVH VVEFNPFESG DSGNLIAYGG SNYVVVGMCT FQEEETDIEG
IQYKTLRTFH HGVRVDGIAW SPETKLDSLP PVIKFCTSAA DLKIRLFTSD LQDKNEYKVL
EGHSDFINDL VFHPKEGQEL ASVSDDHTCR IWNLEGKQTA HFLLHSPGMS VCWHPEETFK
LMVAEKNGTI RFYDLMAQQA ILSLQSEQTP LMSAHWCLKN TFKVGAVAGN DWIIWDITRS
SYPQETRPVH MDRAHLFRWS AISENLFATT GYPGKMASQF QIHHLGHSQP VLIGSVAVGS
GLSWHRTLPL CAVGGDHKLL FWVTEI
