ID   NUP42_CHICK             Reviewed;         413 AA.
AC   Q5ZI22;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Nucleoporin NUP42 {ECO:0000305};
DE   AltName: Full=Nucleoporin-like protein 2;
GN   Name=NUP42; Synonyms=NUPL2; ORFNames=RCJMB04_31e20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC       from the nucleus into the cytoplasm. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the nuclear pore complex (NPC).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC       Nucleus membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- DOMAIN: The FG repeats are interaction sites for karyopherins
CC       (importins, exportins) and form probably an affinity gradient, guiding
CC       the transport proteins unidirectionally with their cargo through the
CC       NPC. {ECO:0000250}.
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DR   EMBL; AJ720962; CAG32621.1; -; mRNA.
DR   RefSeq; NP_001026155.1; NM_001030984.1.
DR   AlphaFoldDB; Q5ZI22; -.
DR   SMR; Q5ZI22; -.
DR   STRING; 9031.ENSGALP00000017786; -.
DR   PaxDb; Q5ZI22; -.
DR   GeneID; 420614; -.
DR   KEGG; gga:420614; -.
DR   CTD; 11097; -.
DR   VEuPathDB; HostDB:geneid_420614; -.
DR   eggNOG; ENOG502R2TD; Eukaryota.
DR   InParanoid; Q5ZI22; -.
DR   OrthoDB; 1562631at2759; -.
DR   PhylomeDB; Q5ZI22; -.
DR   PRO; PR:Q5ZI22; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..413
FT                   /note="Nucleoporin NUP42"
FT                   /id="PRO_0000204898"
FT   REPEAT          14..15
FT                   /note="FG 1"
FT   REPEAT          79..80
FT                   /note="FG 2"
FT   REPEAT          217..218
FT                   /note="FG 3"
FT   REPEAT          225..226
FT                   /note="FG 4"
FT   REPEAT          269..270
FT                   /note="FG 5"
FT   REPEAT          313..314
FT                   /note="FG 6"
FT   ZN_FING         1..25
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          252..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  42317 MW;  763304BFE894F1F1 CRC64;
     MTICQFFLQG RCRFGDRCWN EHPRGGGGRP HSAGPVRGAG GGWGAASQRY ANVIQPPIFK
     HSTWGGSGDG GGFSGASDFG SPGNKSAVFS QNRFSALSSA HPADGFSDEE QRLLDCVAKD
     MATWESSGQW MFSCYSPEAG KPNVSGFREF SAEEVRLEYY NCSANNNTEN YINSVNQLVQ
     ERRNRLQELK ALNASGKESL LSQLKNAVTQ PLPSLGFGGQ QASSFGFPSF PVSSSSGAAS
     FSFKANPSVP PGNAAAVGSS AAASNPPTFG VTSSPSVPNP VGSGNSSAPS AASFSFKTSG
     TTSGCGTSGL SGFGSSAAAN SSSTAPLPVS ATPSAATGTS QSGASSASAA QTAGASGHNV
     TSAPSAVPNG IASDKLYTPR SELTAEELEQ FEAKRFTLGK IPLKPPPIDL LYL