NUP42_DANRE
ID NUP42_DANRE Reviewed; 414 AA.
AC Q6P0U9;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Nucleoporin NUP42 {ECO:0000305};
DE AltName: Full=Nucleoporin-like protein 2;
GN Name=nup42; Synonyms=nupl2; ORFNames=zgc:77724;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. {ECO:0000250}.
CC -!- SUBUNIT: Probable component of the nuclear pore complex (NPC).
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:O15504}. Nucleus membrane
CC {ECO:0000250|UniProtKB:O15504}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O15504}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:O15504}.
CC -!- DOMAIN: The FG repeats are interaction sites for karyopherins
CC (importins, exportins) and form probably an affinity gradient, guiding
CC the transport proteins unidirectionally with their cargo through the
CC NPC. {ECO:0000250}.
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DR EMBL; BC065440; AAH65440.1; -; mRNA.
DR RefSeq; NP_998375.1; NM_213210.1.
DR AlphaFoldDB; Q6P0U9; -.
DR SMR; Q6P0U9; -.
DR STRING; 7955.ENSDARP00000050124; -.
DR PaxDb; Q6P0U9; -.
DR PRIDE; Q6P0U9; -.
DR Ensembl; ENSDART00000050125; ENSDARP00000050124; ENSDARG00000029043.
DR GeneID; 406491; -.
DR KEGG; dre:406491; -.
DR CTD; 11097; -.
DR ZFIN; ZDB-GENE-040426-2292; nup42.
DR eggNOG; ENOG502R2TD; Eukaryota.
DR GeneTree; ENSGT00390000000118; -.
DR HOGENOM; CLU_048441_0_0_1; -.
DR InParanoid; Q6P0U9; -.
DR OMA; FEAKKFT; -.
DR OrthoDB; 1562631at2759; -.
DR PhylomeDB; Q6P0U9; -.
DR TreeFam; TF106503; -.
DR Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DRE-191859; snRNP Assembly.
DR Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR PRO; PR:Q6P0U9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000029043; Expressed in testis and 27 other tissues.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR000571; Znf_CCCH.
DR SMART; SM00356; ZnF_C3H1; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW Zinc; Zinc-finger.
FT CHAIN 1..414
FT /note="Nucleoporin NUP42"
FT /id="PRO_0000204899"
FT REPEAT 43..44
FT /note="FG 1"
FT REPEAT 207..208
FT /note="FG 2"
FT REPEAT 214..215
FT /note="FG 3"
FT REPEAT 221..222
FT /note="FG 5"
FT REPEAT 233..234
FT /note="FG 6"
FT REPEAT 238..239
FT /note="FG 4"
FT REPEAT 257..258
FT /note="FG 7"
FT REPEAT 268..269
FT /note="FG 8"
FT REPEAT 280..281
FT /note="FG 9"
FT REPEAT 306..307
FT /note="FG 10"
FT REPEAT 325..326
FT /note="FG 11"
FT REPEAT 329..330
FT /note="FG 12"
FT REPEAT 335..336
FT /note="FG 13"
FT REPEAT 341..342
FT /note="FG 14"
FT REPEAT 347..348
FT /note="FG 15"
FT REPEAT 351..352
FT /note="FG 16"
FT REPEAT 362..363
FT /note="FG 17"
FT ZN_FING 1..25
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 24..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 42580 MW; C067EF0E51E8E1D9 CRC64;
MPVCNFFLQG RCRYGDTCWN EHPTGGRGGD YRGNQQPSNR GGFGNRVWIN PSQRGGGGSS
SAGGSNEWGR GAASARDVQS SEFSFSQNRF SALETQRAGA EDTHTTLDTI QKEMEVWQTS
GQWPFSCYSA VNRQISGFIE LCPEELRLEY YTSRASGDIQ PYINSVQQLA NQWRSRVQEL
RNMSSSTQIS VIAELKSSSP PASAPGFGSP GPGFGSATSG FGNTSLSSPP AGFGGAGFGS
GPQSSSTFSF AQSKTDFGAS NTQQASGFGS SAFAQPSSGF GNPAPSAASF SFAAADSESK
PSAGGFGSAS GFSFKTATAG QGSGFGSGFG SSSGFGSSSG FGSSSGFGSA FGSAAPAQSS
SFGSTGGAAD TQSGHGLFTA NSELTPEELK EFMAKRFTLG QIPLRPPPAD LLMI
