ID   NUP42_PONAB             Reviewed;         423 AA.
AC   Q5RB98;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Nucleoporin NUP42 {ECO:0000305};
DE   AltName: Full=Nucleoporin-like protein 2;
GN   Name=NUP42; Synonyms=NUPL2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC       from the nucleus into the cytoplasm. {ECO:0000250|UniProtKB:O15504}.
CC   -!- SUBUNIT: Probable component of the nuclear pore complex (NPC).
CC       Interacts with nuclear export protein NXF1. Interacts with GLE1. Able
CC       to form a heterotrimer with NUP155 and GLE1 in vitro (By similarity).
CC       Interacts with XPO1 (By similarity). {ECO:0000250|UniProtKB:O15504}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:O15504}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:O15504}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O15504}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:O15504}. Note=Excluded from the nucleolus.
CC       {ECO:0000250|UniProtKB:O15504}.
CC   -!- DOMAIN: The FG repeats are interaction sites for karyopherins
CC       (importins, exportins) and form probably an affinity gradient, guiding
CC       the transport proteins unidirectionally with their cargo through the
CC       NPC. {ECO:0000250|UniProtKB:O15504}.
CC   -!- PTM: O-glycosylated. {ECO:0000250|UniProtKB:O15504}.
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DR   EMBL; CR858753; CAH90962.1; -; mRNA.
DR   RefSeq; NP_001125554.1; NM_001132082.1.
DR   AlphaFoldDB; Q5RB98; -.
DR   SMR; Q5RB98; -.
DR   STRING; 9601.ENSPPYP00000019876; -.
DR   GeneID; 100172467; -.
DR   KEGG; pon:100172467; -.
DR   CTD; 11097; -.
DR   eggNOG; ENOG502R2TD; Eukaryota.
DR   InParanoid; Q5RB98; -.
DR   OrthoDB; 1562631at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Metal-binding; mRNA transport;
KW   Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport; Zinc; Zinc-finger.
FT   CHAIN           1..423
FT                   /note="Nucleoporin NUP42"
FT                   /id="PRO_0000204897"
FT   REPEAT          14..15
FT                   /note="FG 1"
FT   REPEAT          80..81
FT                   /note="FG 2"
FT   REPEAT          95..96
FT                   /note="FG 3"
FT   REPEAT          218..219
FT                   /note="FG 4"
FT   REPEAT          220..221
FT                   /note="FG 5"
FT   REPEAT          271..272
FT                   /note="FG 6"
FT   REPEAT          288..289
FT                   /note="FG 7"
FT   REPEAT          290..291
FT                   /note="FG 8"
FT   REPEAT          311..312
FT                   /note="FG 9"
FT   REPEAT          336..337
FT                   /note="FG 10"
FT   REPEAT          345..346
FT                   /note="FG 11"
FT   REPEAT          364..365
FT                   /note="FG 12"
FT   ZN_FING         1..25
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          24..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         106
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15504"
SQ   SEQUENCE   423 AA;  44822 MW;  4D01E9411B004297 CRC64;
     MAICQFFLQG RCRFGDRCWN EHPGARGAGG GRQQPQLQPS GNNRRGWNTT SQRYSNVIQS
     SSFSKSTPWG GSRDQEKPSF GSFDSGASTN RKEGFGLSEN PFASLSPDEQ KDEKKLLEGI
     VKDMEVWESS GQWMFSVYSP VKKKPNISGF TDISPEELRL EYHNFLTSNN LQSYLNSVQR
     LINQWRNRVN ELKSLNISTK VALLSDVKDG VNQAAPAFGF GSSQAATFVS PGFPVNNSSS
     DNAQNFSFKT NSGFAAASSG SPAGFRSSPA FGAAASTSSA ISTSAPAFGF GKPEVTSAAS
     FSFKSPAASS FGSPGFSGLP ASLATGPVRA PVAPAFGGGS SVAGFGSLGS HSHAAFSKPS
     SDTFGNSSIS TSLSASSSII ATDNVLFTPR DKLTVEELEQ FQSKKFTLGK IPLKPPPLEL
     LNI