ID   NUP42_XENLA             Reviewed;         491 AA.
AC   Q5XGN1; Q4QQY9;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Nucleoporin NUP42 {ECO:0000305};
DE   AltName: Full=Nucleoporin-like protein 2;
GN   Name=nup42; Synonyms=nupl2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 7-491 (ISOFORM 2).
RC   TISSUE=Egg, and Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC       from the nucleus into the cytoplasm. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the nuclear pore complex (NPC).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:O15504}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:O15504}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O15504}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:O15504}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5XGN1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5XGN1-2; Sequence=VSP_016485;
CC   -!- DOMAIN: The FG repeats are interaction sites for karyopherins
CC       (importins, exportins) and form probably an affinity gradient, guiding
CC       the transport proteins unidirectionally with their cargo through the
CC       NPC. {ECO:0000250}.
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DR   EMBL; BC084406; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC097795; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q5XGN1; -.
DR   SMR; Q5XGN1; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Metal-binding; mRNA transport;
KW   Nuclear pore complex; Nucleus; Protein transport; Reference proteome;
KW   Repeat; Translocation; Transport; Zinc; Zinc-finger.
FT   CHAIN           1..491
FT                   /note="Nucleoporin NUP42"
FT                   /id="PRO_0000204900"
FT   REPEAT          110..111
FT                   /note="FG 1"
FT   REPEAT          259..260
FT                   /note="FG 2"
FT   REPEAT          302..303
FT                   /note="FG 3"
FT   REPEAT          312..313
FT                   /note="FG 4"
FT   REPEAT          333..334
FT                   /note="FG 5"
FT   REPEAT          342..343
FT                   /note="FG 6"
FT   REPEAT          363..364
FT                   /note="FG 7"
FT   REPEAT          375..376
FT                   /note="FG 8"
FT   REPEAT          379..380
FT                   /note="FG 9"
FT   REPEAT          410..411
FT                   /note="FG 10"
FT   ZN_FING         1..25
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          23..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          92..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         48..53
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_016485"
FT   CONFLICT        38
FT                   /note="N -> S (in Ref. 1; BC097795)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        131
FT                   /note="A -> T (in Ref. 1; BC097795)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   491 AA;  51705 MW;  A292D78C705F9DD6 CRC64;
     MAICNFFLQG RCRYGEKCWN EHPRGGGGGG GNRYQSQNRY QEQSRYQEQS RYPEQSRYPE
     QNRYQEPAGN AKGTWGASSQ RYVQPSNFSK STTWINRDSE KPSAGSFSGF GSRNVKSTAA
     TGLPSTQNRF AALSSQDNSR DGQTDKGNIL DDIMKDMEIW ESSGQWMFSV YSMLKEKKNI
     SGFTDFSPEE LRLEYSVCQA EGNPLKYINA VQQLGSKWKQ RILELKNPNP SIKTALLNEL
     NSPSPDVTPG YSGQQNSAFG ALSFPTSNTA PTAVTFSFKA DTTTAAKPAV PNALAGSDFS
     AFGNKPTSAP SFGSGVAAAA ASFSFAPSTI SGFGSTASNS GFGAASNAAG FQGAANIAAA
     PAFGVASSTA PASGFGGGFG TTVNTGAKTS SVRDLFSAGT AVPVQTTLLF GQATGSLNTT
     ASSTSLAGQP FKASTSATAV SGSFTSDNTS NPLFTPRNEL SVEDLAQFEA KQFTLGKTPI
     KPPSADLLKV T