ID   NUP42_XENTR             Reviewed;         449 AA.
AC   Q5FVW4;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Nucleoporin NUP42 {ECO:0000305};
DE   AltName: Full=Nucleoporin-like protein 2;
GN   Name=nup42; Synonyms=nupl2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=F6;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC       from the nucleus into the cytoplasm. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the nuclear pore complex (NPC).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:O15504}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:O15504}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O15504}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:O15504}.
CC   -!- DOMAIN: The FG repeats are interaction sites for karyopherins
CC       (importins, exportins) and form probably an affinity gradient, guiding
CC       the transport proteins unidirectionally with their cargo through the
CC       NPC. {ECO:0000250}.
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DR   EMBL; BC089742; AAH89742.1; -; mRNA.
DR   RefSeq; NP_001015793.1; NM_001015793.2.
DR   RefSeq; XP_012820097.1; XM_012964643.2.
DR   RefSeq; XP_012820099.1; XM_012964645.2.
DR   RefSeq; XP_012820100.1; XM_012964646.2.
DR   RefSeq; XP_012820101.1; XM_012964647.2.
DR   AlphaFoldDB; Q5FVW4; -.
DR   SMR; Q5FVW4; -.
DR   STRING; 8364.ENSXETP00000013054; -.
DR   PaxDb; Q5FVW4; -.
DR   DNASU; 548510; -.
DR   Ensembl; ENSXETT00000013054; ENSXETP00000013054; ENSXETG00000005935.
DR   GeneID; 548510; -.
DR   KEGG; xtr:548510; -.
DR   CTD; 11097; -.
DR   Xenbase; XB-GENE-6258607; nup42.
DR   eggNOG; ENOG502R2TD; Eukaryota.
DR   HOGENOM; CLU_048441_0_0_1; -.
DR   InParanoid; Q5FVW4; -.
DR   OMA; CHNEHFD; -.
DR   OrthoDB; 1562631at2759; -.
DR   PhylomeDB; Q5FVW4; -.
DR   TreeFam; TF106503; -.
DR   Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005935; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000571; Znf_CCCH.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..449
FT                   /note="Nucleoporin NUP42"
FT                   /id="PRO_0000204901"
FT   REPEAT          231..232
FT                   /note="FG 1"
FT   REPEAT          274..275
FT                   /note="FG 2"
FT   REPEAT          284..285
FT                   /note="FG 3"
FT   REPEAT          305..306
FT                   /note="FG 4"
FT   REPEAT          314..315
FT                   /note="FG 5"
FT   REPEAT          335..336
FT                   /note="FG 6"
FT   REPEAT          347..348
FT                   /note="FG 7"
FT   ZN_FING         1..25
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          22..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  47344 MW;  EB0D177099444921 CRC64;
     MAICSFFLQG RCRYGEKCWN EHPRGGSSRY QSQNRYQEPP GNAKGTWGSS SQRYVQPSSF
     SRSTTWVNRD NEKPSSGSHS GFDNRNVKFT AATGFPSSQN RFAALSSQDN SRDAQTDKGN
     IIDDITNDME IWESSGQWMF SVYSMLREKK NISGFADFSP EELRLEYYAC QAEGNPLKYI
     NAVQQLGSKW KQRILELKNL NPSSKMALFN ELSSPSSDMT SGYNGQQKPA FGSSSFPTNN
     TAPTAATFSF KADAANAAKA GATNSLAGSN VPAFGNKPTS APSFGSGGAA TAASFSFAPS
     SSSNFGATTS TSGFGNASNT ASFQGTANSA AAPAFGVASS STAATGFGGG FSTTGAMNTG
     VRDLFSAGTV GPGPVTSLFV QTTGPLHATA SSTSLDGQSF RPSALNTTNS LFTPQNELSA
     EELAQFKAQR FTLGKIPLKP PPADLLNVS