NUP43_ARATH
ID NUP43_ARATH Reviewed; 361 AA.
AC Q24JJ9; O65565; Q8LCD6;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Nuclear pore complex protein NUP43 {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin 43;
GN Name=NUP43 {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At4g30840 {ECO:0000312|Araport:AT4G30840};
GN ORFNames=F6I18.250 {ECO:0000312|EMBL:CAA18209.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:ABD85161.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX, SUBCELLULAR LOCATION, AND
RP NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21189294}.
CC Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63718.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA18209.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79802.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL022198; CAA18209.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161577; CAB79802.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85817.1; -; Genomic_DNA.
DR EMBL; BT024890; ABD85161.1; -; mRNA.
DR EMBL; AY086661; AAM63718.1; ALT_INIT; mRNA.
DR PIR; A85361; A85361.
DR RefSeq; NP_567858.1; NM_119231.3.
DR AlphaFoldDB; Q24JJ9; -.
DR SMR; Q24JJ9; -.
DR BioGRID; 14495; 176.
DR STRING; 3702.AT4G30840.1; -.
DR PaxDb; Q24JJ9; -.
DR PRIDE; Q24JJ9; -.
DR ProteomicsDB; 248750; -.
DR EnsemblPlants; AT4G30840.1; AT4G30840.1; AT4G30840.
DR GeneID; 829208; -.
DR Gramene; AT4G30840.1; AT4G30840.1; AT4G30840.
DR KEGG; ath:AT4G30840; -.
DR Araport; AT4G30840; -.
DR TAIR; locus:2126689; AT4G30840.
DR eggNOG; ENOG502QVRC; Eukaryota.
DR HOGENOM; CLU_795380_0_0_1; -.
DR InParanoid; Q24JJ9; -.
DR OMA; SPCESEV; -.
DR OrthoDB; 658269at2759; -.
DR PhylomeDB; Q24JJ9; -.
DR PRO; PR:Q24JJ9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q24JJ9; baseline and differential.
DR Genevisible; Q24JJ9; AT.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..361
FT /note="Nuclear pore complex protein NUP43"
FT /id="PRO_0000431093"
FT REPEAT 132..173
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 177..215
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 225..265
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REGION 51..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 124
FT /note="F -> V (in Ref. 4; AAM63718)"
SQ SEQUENCE 361 AA; 39354 MW; CD98DF9A4866BD32 CRC64;
MEMMQDSFQV HRIPQSKYVD GVRWLPQASA LNRFFATASY DADCDSSSIE IQSLDPNPRG
NHNTNPLIES LSSWTSPSRV SSLEVAGNGG GGGSFKPMVS AATSSGSLHV LMIDLVEGAA
IEEFYAAEGE RFHVGRVEGV DWREGGECVT VGEDGRVNVV KIVNGEGLRY RKVFDGNGLV
AYRAVKWASP TEFVTGGYGF GLQLWDQRKS GEAVSQLKGN WFQGKTSAIV HSIDIHPSRK
HTCIAGGSSG TVFAWDLRWP QQPIVLSGVG ASENINNPLS ESEVWEVQYD SYTKSNVSSS
RILPVMTCSE DGILGIIEQG EEPIELLAEP CAINSFDIDR QNPQDVICSL EWESIAVFSR
P
