ID   NUP43_DICDI             Reviewed;         417 AA.
AC   Q54Z22;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Nuclear pore complex protein nup43;
DE   AltName: Full=Nucleoporin nup43;
GN   Name=nup43; ORFNames=DDB_G0277955;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the nuclear pore complex, a complex required for
CC       the trafficking across the nuclear membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC       Nucleus membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUP43 family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68150.1; -; Genomic_DNA.
DR   RefSeq; XP_642030.1; XM_636938.1.
DR   AlphaFoldDB; Q54Z22; -.
DR   SMR; Q54Z22; -.
DR   STRING; 44689.DDB0235245; -.
DR   TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR   PaxDb; Q54Z22; -.
DR   EnsemblProtists; EAL68150; EAL68150; DDB_G0277955.
DR   GeneID; 8621241; -.
DR   KEGG; ddi:DDB_G0277955; -.
DR   dictyBase; DDB_G0277955; nup43.
DR   eggNOG; KOG4714; Eukaryota.
DR   HOGENOM; CLU_659598_0_0_1; -.
DR   InParanoid; Q54Z22; -.
DR   OMA; RLICCST; -.
DR   PhylomeDB; Q54Z22; -.
DR   PRO; PR:Q54Z22; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT   CHAIN           1..417
FT                   /note="Nuclear pore complex protein nup43"
FT                   /id="PRO_0000393273"
FT   REPEAT          13..57
FT                   /note="WD 1"
FT   REPEAT          68..106
FT                   /note="WD 2"
FT   REPEAT          188..227
FT                   /note="WD 3"
FT   REPEAT          231..270
FT                   /note="WD 4"
FT   REPEAT          275..315
FT                   /note="WD 5"
FT   REPEAT          318..358
FT                   /note="WD 6"
FT   REGION          152..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  47124 MW;  B9384516CEB96D5A CRC64;
     MSSVSVHYST HKINKVRFLN RNFHNDTSLF VTGTNHPVLS KNKISVWGLE SRQNSDEIEE
     LASVPIDGIV TELKVIEINN KPMIIGSTSK GSIFMYSIFN LPNKFEYIGY DGLLDKKYEN
     YNNINNINDT YDTCNLLKER IWFNSSSNNN NVNSNNINNN NYNNNNNNYN NNNNNNNNNN
     NNNNNNNNNG SCINSFDISY DQHSLVTVGN DGVMNLLSIE NLIPIYTNRY IDGLSVNVVK
     SITSNQIITS GELGRYIKFW DIRSNSSQPV KTIKTQCPRI FSLAIHKDEQ HIIAAGSSDG
     QVNLFDIRND YSIDQNKTHN SNVWELSFSK SNPNQLYSCS EDGFIYQYSY NKDNLGGGGM
     MTLPNQINNT FDIYSKEVSL LQLPTSIGSI DSFDINSNIN RLICCSTSSQ CLIVKSL