NUP44_SCHPO
ID NUP44_SCHPO Reviewed; 403 AA.
AC O42963; P78918; Q1L840;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Nucleoporin nup44;
DE AltName: Full=Nuclear pore protein nup44;
GN Name=nup44; ORFNames=SPBC19G7.15;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15116432; DOI=10.1002/yea.1115;
RA Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.;
RT "Identification of genes encoding putative nucleoporins and transport
RT factors in the fission yeast Schizosaccharomyces pombe: a deletion
RT analysis.";
RL Yeast 21:495-509(2004).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. Active directional transport is assured by both, a Phe-Gly
CC (FG) repeat affinity gradient for these transport factors across the
CC NPC and a transport cofactor concentration gradient across the nuclear
CC envelope. {ECO:0000269|PubMed:15116432}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13930.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D89269; BAA13930.1; ALT_FRAME; mRNA.
DR EMBL; CU329671; CAA17069.1; -; Genomic_DNA.
DR PIR; T39846; T39846.
DR PIR; T43197; T43197.
DR RefSeq; NP_595981.1; NM_001021888.2.
DR AlphaFoldDB; O42963; -.
DR SMR; O42963; -.
DR BioGRID; 277295; 3.
DR IntAct; O42963; 1.
DR STRING; 4896.SPBC19G7.15.1; -.
DR iPTMnet; O42963; -.
DR MaxQB; O42963; -.
DR PaxDb; O42963; -.
DR PRIDE; O42963; -.
DR EnsemblFungi; SPBC19G7.15.1; SPBC19G7.15.1:pep; SPBC19G7.15.
DR GeneID; 2540775; -.
DR KEGG; spo:SPBC19G7.15; -.
DR PomBase; SPBC19G7.15; nup44.
DR VEuPathDB; FungiDB:SPBC19G7.15; -.
DR eggNOG; KOG3091; Eukaryota.
DR HOGENOM; CLU_023804_0_1_1; -.
DR InParanoid; O42963; -.
DR OMA; QKRINMQ; -.
DR PhylomeDB; O42963; -.
DR Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-SPO-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-SPO-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-SPO-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-SPO-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR PRO; PR:O42963; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR GO; GO:0036228; P:protein localization to nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0006407; P:rRNA export from nucleus; ISO:PomBase.
DR InterPro; IPR024864; Nup54/Nup57/Nup44.
DR InterPro; IPR025712; Nup54_alpha-helical_dom.
DR PANTHER; PTHR13000; PTHR13000; 1.
DR Pfam; PF13874; Nup54; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Transport.
FT CHAIN 1..403
FT /note="Nucleoporin nup44"
FT /id="PRO_0000290671"
FT REGION 1..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="F -> L (in Ref. 1; BAA13930)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="T -> P (in Ref. 1; BAA13930)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="I -> F (in Ref. 1; BAA13930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 403 AA; 44484 MW; 17FA9FBE1FE55C98 CRC64;
MAFSFGQQGS SIKAPSIGST GVFGQSNTTK PTAPFGSGSI FGSTNTNVGA GGPTGSSSAP
PFGNSIFGKT QQQPTTSFSN TTTNAPQSTV FGQNAASRTG NSNTQPLFSW STVNNPTKPV
DETNATIPSS LLLSSGISPN ATVSNAQYGP AQPPSVEEQV QKILNAWNLN HPDCAFQRFF
YNKVPVEQAA LYVKPPNYNQ QKWDEAVANR PSNSVVPVLA VGFPDVQKRI NMQIQQVNTY
RIRMREIVET LGRLSNKHDL DFSIKLAEAK NRHVRLSERI LRLAIKVHVL RHRGYALKPN
EEELRKKLDD LTKSLNNPEI FGRLNEIWAR ITLIFEGEKI SEDQRSNLAK GVVDWRKNSD
QLEVITDVLR DHQVGLSYVV KLMQEDLATL NKQLTEHVPQ SQK
