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NUP54_ARATH
ID   NUP54_ARATH             Reviewed;         377 AA.
AC   Q8GYF7; O48698;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Nuclear pore complex protein NUP54 {ECO:0000303|PubMed:21189294};
DE   AltName: Full=Nucleoporin 54;
GN   Name=NUP54 {ECO:0000303|PubMed:21189294};
GN   OrderedLocusNames=At1g24310 {ECO:0000312|Araport:AT1G24310};
GN   ORFNames=F3I6.25 {ECO:0000312|EMBL:AAC00594.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:BAC42318.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND NOMENCLATURE.
RX   PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA   Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT   "Identification and characterization of nuclear pore complex components in
RT   Arabidopsis thaliana.";
RL   Plant Cell 22:4084-4097(2010).
CC   -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC       fold symmetrical structure comprising a central transport channel and
CC       two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC       are attached. The cytoplasmic filaments have loose ends, while the
CC       nuclear filaments are joined in a distal ring, forming a nuclear
CC       basket. NPCs are highly dynamic in configuration and composition, and
CC       can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC       subcomplex and the NUP93 subcomplex, containing approximately 30
CC       different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21189294}.
CC       Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}.
CC   -!- DOMAIN: Contains FG repeats mediating the translocation through the NPC
CC       by interacting with transport factors. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NUP54 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC00594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC002396; AAC00594.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE30515.1; -; Genomic_DNA.
DR   EMBL; AK117665; BAC42318.1; -; mRNA.
DR   EMBL; BT004977; AAO50510.1; -; mRNA.
DR   PIR; T00662; T00662.
DR   RefSeq; NP_173841.1; NM_102277.4.
DR   AlphaFoldDB; Q8GYF7; -.
DR   SMR; Q8GYF7; -.
DR   BioGRID; 24285; 5.
DR   IntAct; Q8GYF7; 1.
DR   STRING; 3702.AT1G24310.1; -.
DR   MetOSite; Q8GYF7; -.
DR   PaxDb; Q8GYF7; -.
DR   PRIDE; Q8GYF7; -.
DR   ProteomicsDB; 249355; -.
DR   EnsemblPlants; AT1G24310.1; AT1G24310.1; AT1G24310.
DR   GeneID; 839047; -.
DR   Gramene; AT1G24310.1; AT1G24310.1; AT1G24310.
DR   KEGG; ath:AT1G24310; -.
DR   Araport; AT1G24310; -.
DR   TAIR; locus:2032417; AT1G24310.
DR   eggNOG; KOG3091; Eukaryota.
DR   HOGENOM; CLU_058537_0_0_1; -.
DR   InParanoid; Q8GYF7; -.
DR   OMA; NVMKRDT; -.
DR   OrthoDB; 1506658at2759; -.
DR   PhylomeDB; Q8GYF7; -.
DR   PRO; PR:Q8GYF7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8GYF7; baseline and differential.
DR   Genevisible; Q8GYF7; AT.
DR   GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR   GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0036228; P:protein localization to nuclear inner membrane; IBA:GO_Central.
DR   InterPro; IPR024864; Nup54/Nup57/Nup44.
DR   InterPro; IPR025712; Nup54_alpha-helical_dom.
DR   PANTHER; PTHR13000; PTHR13000; 1.
DR   Pfam; PF13874; Nup54; 1.
PE   1: Evidence at protein level;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport.
FT   CHAIN           1..377
FT                   /note="Nuclear pore complex protein NUP54"
FT                   /id="PRO_0000431083"
FT   REPEAT          2..3
FT                   /note="1"
FT   REPEAT          11..12
FT                   /note="2"
FT   REPEAT          20..21
FT                   /note="3"
FT   REPEAT          27..28
FT                   /note="4"
FT   REPEAT          36..37
FT                   /note="5"
FT   REPEAT          49..50
FT                   /note="6"
FT   REPEAT          87..88
FT                   /note="7"
FT   REGION          1..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..88
FT                   /note="7 X 2 AA repeats of F-G"
SQ   SEQUENCE   377 AA;  41817 MW;  3F840C02CDB3B39E CRC64;
     MFGTPSSSPS FGTPSSTPAF GTSSPAFGTP SATPAFGTPS NPSFSSGGFG SSLFSSPFSS
     QQPQQQQQQQ QQQQPSSLFQ QQPSSNFGFQ SPFNNTAQQQ QQTPFPNAQL TTQMAPVAPI
     PYSLADRDVQ AIIEAYKEDP TNPKYAFQHL LFSVTEPQYR VKPAAVSDIM WAEAMSKLEG
     MDSTERERLW PQLVQGFKDL SQRLKLQDEV LVSDRDRIKT TQSNVKMLQR HLQASTFPSI
     ERLRQKEQSL QRRMLRVMRI IEGLEGKGFR LPLTKGEAEL SEKLTAITRQ VKGPGAELSR
     RVQSLQTISR AQANSIAAGS SLYLPGSTKI DEQSLIDMQE VLQQETEAIG RLGNVLKRDM
     RDMEIMVAED TEMALDS
 
 
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