ID   NUP54_DICDI             Reviewed;         440 AA.
AC   Q55BX5;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Nuclear pore complex protein nup54;
DE   AltName: Full=Nucleoporin nup54;
GN   Name=nup54; ORFNames=DDB_G0270320;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable component of the nuclear pore complex, a complex
CC       required for the trafficking across the nuclear membrane.
CC       {ECO:0000250|UniProtKB:P70582}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:P70582}.
CC   -!- DOMAIN: Contains FG repeats.
CC   -!- SIMILARITY: Belongs to the NUP54 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72510.1; -; Genomic_DNA.
DR   RefSeq; XP_646706.1; XM_641614.1.
DR   AlphaFoldDB; Q55BX5; -.
DR   SMR; Q55BX5; -.
DR   STRING; 44689.DDB0235246; -.
DR   PaxDb; Q55BX5; -.
DR   PRIDE; Q55BX5; -.
DR   EnsemblProtists; EAL72510; EAL72510; DDB_G0270320.
DR   GeneID; 8617680; -.
DR   KEGG; ddi:DDB_G0270320; -.
DR   dictyBase; DDB_G0270320; nup54.
DR   eggNOG; KOG3091; Eukaryota.
DR   HOGENOM; CLU_623217_0_0_1; -.
DR   InParanoid; Q55BX5; -.
DR   OMA; VYNKVNE; -.
DR   PhylomeDB; Q55BX5; -.
DR   PRO; PR:Q55BX5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0036228; P:protein localization to nuclear inner membrane; IBA:GO_Central.
DR   InterPro; IPR025574; Nucleoporin_FG_rpt.
DR   InterPro; IPR024864; Nup54/Nup57/Nup44.
DR   InterPro; IPR025712; Nup54_alpha-helical_dom.
DR   PANTHER; PTHR13000; PTHR13000; 2.
DR   Pfam; PF13634; Nucleoporin_FG; 2.
DR   Pfam; PF13874; Nup54; 1.
PE   3: Inferred from homology;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport.
FT   CHAIN           1..440
FT                   /note="Nuclear pore complex protein nup54"
FT                   /id="PRO_0000393274"
FT   REPEAT          4..5
FT                   /note="1"
FT   REPEAT          15..16
FT                   /note="2"
FT   REPEAT          30..31
FT                   /note="3"
FT   REPEAT          40..41
FT                   /note="4"
FT   REPEAT          54..55
FT                   /note="5"
FT   REPEAT          71..72
FT                   /note="6"
FT   REPEAT          85..86
FT                   /note="7"
FT   REPEAT          98..99
FT                   /note="8"
FT   REPEAT          109..110
FT                   /note="9"
FT   REPEAT          171..172
FT                   /note="10"
FT   REPEAT          183..184
FT                   /note="11"
FT   REGION          1..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..184
FT                   /note="11 X 2 AA repeats of F-G"
SQ   SEQUENCE   440 AA;  48205 MW;  65D6CD143129E48A CRC64;
     MSLFGNTTTG GGGLFGNTTT PTQTTGGGLF GNTTTGGGLF GNTATPTTGG GGLFGNTATP
     TLTTGGGGGL FGNTTAPTTG GGGLFGNTPT QTTGGGLFGN TATGGGGLFG NTQQQQQQQQ
     QQQQQQQQQQ QQQPSTSLFS QSSLGSQSSL GSQSSLGSQS SLGSQSSLGS FGQTQQPQTS
     SLFGNLQQQQ QLQQPQRSII EQKLYDFMQS ISPNSLNCRF LYWFYNYQAN GQLVDPNSIP
     KPPNVTVDQW AYALSNNPDP SILIPVAAKS FDDLINRRMK QEETIIALDQ NTQEALKRMR
     DLENHLNFHI HTQLEMMRKK QIELIQRYIE VWSNLEIYQS KGKTFTTSEE RIMKKIYELF
     EEINQPNSIK SKVEEISNQL KLGSMEKEKI KYEISPEAVE PLYNLLKNMT ISIERITNEL
     EIAVKDAQIL KNELYQLKKC