NUP54_HUMAN
ID NUP54_HUMAN Reviewed; 507 AA.
AC Q7Z3B4; B2RCK7; B4DT35; Q96EA7; Q9NVL5; Q9P0I1;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Nucleoporin p54;
DE AltName: Full=54 kDa nucleoporin;
GN Name=NUP54;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pituitary;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrial tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Component of the nuclear pore complex, a complex required for
CC the trafficking across the nuclear membrane.
CC {ECO:0000250|UniProtKB:P70582}.
CC -!- SUBUNIT: Component of the p62 complex, a complex composed of NUP62,
CC NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with
CC NUTF2. {ECO:0000250|UniProtKB:P70582}.
CC -!- INTERACTION:
CC Q7Z3B4; O95994: AGR2; NbExp=3; IntAct=EBI-741048, EBI-712648;
CC Q7Z3B4; Q10567-3: AP1B1; NbExp=3; IntAct=EBI-741048, EBI-11978055;
CC Q7Z3B4; P63010-2: AP2B1; NbExp=3; IntAct=EBI-741048, EBI-11529439;
CC Q7Z3B4; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-741048, EBI-953896;
CC Q7Z3B4; Q9NWQ9: C14orf119; NbExp=5; IntAct=EBI-741048, EBI-725606;
CC Q7Z3B4; Q9NX04: C1orf109; NbExp=5; IntAct=EBI-741048, EBI-8643161;
CC Q7Z3B4; P55212: CASP6; NbExp=3; IntAct=EBI-741048, EBI-718729;
CC Q7Z3B4; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-741048, EBI-10175300;
CC Q7Z3B4; P06307: CCK; NbExp=3; IntAct=EBI-741048, EBI-6624398;
CC Q7Z3B4; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-741048, EBI-396137;
CC Q7Z3B4; Q9H3R5: CENPH; NbExp=3; IntAct=EBI-741048, EBI-1003700;
CC Q7Z3B4; O75935-2: DCTN3; NbExp=3; IntAct=EBI-741048, EBI-12091947;
CC Q7Z3B4; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-741048, EBI-743105;
CC Q7Z3B4; O00303: EIF3F; NbExp=3; IntAct=EBI-741048, EBI-711990;
CC Q7Z3B4; Q9NYK6-3: EURL; NbExp=3; IntAct=EBI-741048, EBI-13371226;
CC Q7Z3B4; Q9NV70: EXOC1; NbExp=4; IntAct=EBI-741048, EBI-1045313;
CC Q7Z3B4; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-741048, EBI-742102;
CC Q7Z3B4; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-741048, EBI-2514791;
CC Q7Z3B4; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-741048, EBI-2558143;
CC Q7Z3B4; O14964: HGS; NbExp=7; IntAct=EBI-741048, EBI-740220;
CC Q7Z3B4; P30519: HMOX2; NbExp=3; IntAct=EBI-741048, EBI-712096;
CC Q7Z3B4; Q86YM7: HOMER1; NbExp=3; IntAct=EBI-741048, EBI-746815;
CC Q7Z3B4; Q8IY31: IFT20; NbExp=3; IntAct=EBI-741048, EBI-744203;
CC Q7Z3B4; Q8IY31-3: IFT20; NbExp=5; IntAct=EBI-741048, EBI-9091197;
CC Q7Z3B4; O14901: KLF11; NbExp=3; IntAct=EBI-741048, EBI-948266;
CC Q7Z3B4; P19012: KRT15; NbExp=4; IntAct=EBI-741048, EBI-739566;
CC Q7Z3B4; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-741048, EBI-3044087;
CC Q7Z3B4; Q14525: KRT33B; NbExp=3; IntAct=EBI-741048, EBI-1049638;
CC Q7Z3B4; P13473-2: LAMP2; NbExp=3; IntAct=EBI-741048, EBI-21591415;
CC Q7Z3B4; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-741048, EBI-10271199;
CC Q7Z3B4; Q9BVL2: NUP58; NbExp=12; IntAct=EBI-741048, EBI-2811583;
CC Q7Z3B4; P37198: NUP62; NbExp=12; IntAct=EBI-741048, EBI-347978;
CC Q7Z3B4; P61970: NUTF2; NbExp=3; IntAct=EBI-741048, EBI-591778;
CC Q7Z3B4; O43482: OIP5; NbExp=3; IntAct=EBI-741048, EBI-536879;
CC Q7Z3B4; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-741048, EBI-2692890;
CC Q7Z3B4; P62826: RAN; NbExp=3; IntAct=EBI-741048, EBI-286642;
CC Q7Z3B4; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-741048, EBI-748621;
CC Q7Z3B4; Q9H7B4: SMYD3; NbExp=3; IntAct=EBI-741048, EBI-347919;
CC Q7Z3B4; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-741048, EBI-12288855;
CC Q7Z3B4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-741048, EBI-742688;
CC Q7Z3B4; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-741048, EBI-2554984;
CC Q7Z3B4; Q9BT92: TCHP; NbExp=3; IntAct=EBI-741048, EBI-740781;
CC Q7Z3B4; Q969V4: TEKT1; NbExp=3; IntAct=EBI-741048, EBI-10180409;
CC Q7Z3B4; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-741048, EBI-12090309;
CC Q7Z3B4; P06753: TPM3; NbExp=6; IntAct=EBI-741048, EBI-355607;
CC Q7Z3B4; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-741048, EBI-2559305;
CC Q7Z3B4; O95229: ZWINT; NbExp=3; IntAct=EBI-741048, EBI-1001132;
CC Q7Z3B4; Q67020: PA; Xeno; NbExp=2; IntAct=EBI-741048, EBI-11514477;
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P70582}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P70582}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P70582}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P70582}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P70582}; Nucleoplasmic side
CC {ECO:0000250|UniProtKB:P70582}. Note=Biased towards cytoplasmic side.
CC Central region of the nuclear pore complex, within the transporter.
CC {ECO:0000250|UniProtKB:P70582}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z3B4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z3B4-2; Sequence=VSP_008740, VSP_008741;
CC Name=3;
CC IsoId=Q7Z3B4-3; Sequence=VSP_054355;
CC -!- DOMAIN: Contains FG repeats.
CC -!- PTM: O-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NUP54 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91735.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF157322; AAF67488.1; -; mRNA.
DR EMBL; AK001517; BAA91735.1; ALT_FRAME; mRNA.
DR EMBL; AK300036; BAG61847.1; -; mRNA.
DR EMBL; AK315160; BAG37604.1; -; mRNA.
DR EMBL; BX538002; CAD97957.1; -; mRNA.
DR EMBL; AC110795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05777.1; -; Genomic_DNA.
DR CCDS; CCDS3576.1; -. [Q7Z3B4-1]
DR CCDS; CCDS63998.1; -. [Q7Z3B4-3]
DR RefSeq; NP_001265532.1; NM_001278603.1. [Q7Z3B4-3]
DR RefSeq; NP_059122.2; NM_017426.3. [Q7Z3B4-1]
DR PDB; 4JNU; X-ray; 1.44 A; A/B/C/D=453-491.
DR PDB; 4JNV; X-ray; 1.85 A; A/B/C/D=453-491.
DR PDB; 4JO7; X-ray; 1.75 A; B/D/F/H=453-491.
DR PDB; 4JO9; X-ray; 2.50 A; A/C=453-491.
DR PDB; 5IJN; EM; 21.40 A; F/L/R/X=1-507.
DR PDB; 5IJO; EM; 21.40 A; F/L/R/X=1-507.
DR PDB; 7PER; EM; 35.00 A; F/L/R/X=1-507.
DR PDBsum; 4JNU; -.
DR PDBsum; 4JNV; -.
DR PDBsum; 4JO7; -.
DR PDBsum; 4JO9; -.
DR PDBsum; 5IJN; -.
DR PDBsum; 5IJO; -.
DR PDBsum; 7PER; -.
DR AlphaFoldDB; Q7Z3B4; -.
DR SMR; Q7Z3B4; -.
DR BioGRID; 119759; 122.
DR ComplexPortal; CPX-873; Nuclear pore complex.
DR IntAct; Q7Z3B4; 84.
DR MINT; Q7Z3B4; -.
DR STRING; 9606.ENSP00000264883; -.
DR TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family.
DR GlyGen; Q7Z3B4; 8 sites, 1 O-linked glycan (8 sites).
DR iPTMnet; Q7Z3B4; -.
DR PhosphoSitePlus; Q7Z3B4; -.
DR BioMuta; NUP54; -.
DR EPD; Q7Z3B4; -.
DR jPOST; Q7Z3B4; -.
DR MassIVE; Q7Z3B4; -.
DR MaxQB; Q7Z3B4; -.
DR PaxDb; Q7Z3B4; -.
DR PeptideAtlas; Q7Z3B4; -.
DR PRIDE; Q7Z3B4; -.
DR ProteomicsDB; 5071; -.
DR ProteomicsDB; 69024; -. [Q7Z3B4-1]
DR ProteomicsDB; 69025; -. [Q7Z3B4-2]
DR Antibodypedia; 24771; 109 antibodies from 23 providers.
DR DNASU; 53371; -.
DR Ensembl; ENST00000264883.8; ENSP00000264883.3; ENSG00000138750.15. [Q7Z3B4-1]
DR Ensembl; ENST00000514987.5; ENSP00000421304.1; ENSG00000138750.15. [Q7Z3B4-3]
DR GeneID; 53371; -.
DR KEGG; hsa:53371; -.
DR MANE-Select; ENST00000264883.8; ENSP00000264883.3; NM_017426.4; NP_059122.2.
DR UCSC; uc003hjs.5; human. [Q7Z3B4-1]
DR CTD; 53371; -.
DR DisGeNET; 53371; -.
DR GeneCards; NUP54; -.
DR HGNC; HGNC:17359; NUP54.
DR HPA; ENSG00000138750; Low tissue specificity.
DR MIM; 607607; gene.
DR neXtProt; NX_Q7Z3B4; -.
DR OpenTargets; ENSG00000138750; -.
DR PharmGKB; PA31853; -.
DR VEuPathDB; HostDB:ENSG00000138750; -.
DR eggNOG; KOG3091; Eukaryota.
DR GeneTree; ENSGT00390000013620; -.
DR HOGENOM; CLU_033371_0_0_1; -.
DR InParanoid; Q7Z3B4; -.
DR OMA; VYNKVNE; -.
DR OrthoDB; 1506658at2759; -.
DR PhylomeDB; Q7Z3B4; -.
DR TreeFam; TF320237; -.
DR PathwayCommons; Q7Z3B4; -.
DR Reactome; R-HSA-1169408; ISG15 antiviral mechanism.
DR Reactome; R-HSA-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-HSA-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-HSA-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-HSA-165054; Rev-mediated nuclear export of HIV RNA.
DR Reactome; R-HSA-168271; Transport of Ribonucleoproteins into the Host Nucleus.
DR Reactome; R-HSA-168276; NS1 Mediated Effects on Host Pathways.
DR Reactome; R-HSA-168325; Viral Messenger RNA Synthesis.
DR Reactome; R-HSA-168333; NEP/NS2 Interacts with the Cellular Export Machinery.
DR Reactome; R-HSA-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR Reactome; R-HSA-180746; Nuclear import of Rev protein.
DR Reactome; R-HSA-180910; Vpr-mediated nuclear import of PICs.
DR Reactome; R-HSA-191859; snRNP Assembly.
DR Reactome; R-HSA-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-HSA-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-HSA-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-HSA-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-HSA-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-HSA-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-HSA-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-HSA-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-HSA-5619107; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC).
DR Reactome; R-HSA-6784531; tRNA processing in the nucleus.
DR Reactome; R-HSA-9609690; HCMV Early Events.
DR Reactome; R-HSA-9610379; HCMV Late Events.
DR Reactome; R-HSA-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR SignaLink; Q7Z3B4; -.
DR SIGNOR; Q7Z3B4; -.
DR BioGRID-ORCS; 53371; 539 hits in 1099 CRISPR screens.
DR ChiTaRS; NUP54; human.
DR GeneWiki; NUP54; -.
DR GenomeRNAi; 53371; -.
DR Pharos; Q7Z3B4; Tbio.
DR PRO; PR:Q7Z3B4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q7Z3B4; protein.
DR Bgee; ENSG00000138750; Expressed in calcaneal tendon and 200 other tissues.
DR ExpressionAtlas; Q7Z3B4; baseline and differential.
DR Genevisible; Q7Z3B4; HS.
DR GO; GO:0005635; C:nuclear envelope; IDA:ComplexPortal.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IC:ComplexPortal.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IC:ComplexPortal.
DR GO; GO:0036228; P:protein localization to nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0006605; P:protein targeting; IEA:Ensembl.
DR GO; GO:0042306; P:regulation of protein import into nucleus; IEA:Ensembl.
DR InterPro; IPR024864; Nup54/Nup57/Nup44.
DR InterPro; IPR025712; Nup54_alpha-helical_dom.
DR InterPro; IPR040985; Nup54_C.
DR PANTHER; PTHR13000; PTHR13000; 1.
DR Pfam; PF13874; Nup54; 1.
DR Pfam; PF18437; Nup54_C; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Glycoprotein; Membrane; mRNA transport;
KW Nuclear pore complex; Nucleus; Protein transport; Reference proteome;
KW Repeat; Translocation; Transport.
FT CHAIN 1..507
FT /note="Nucleoporin p54"
FT /id="PRO_0000204874"
FT REPEAT 5..6
FT /note="1"
FT REPEAT 25..26
FT /note="2"
FT REPEAT 28..29
FT /note="3"
FT REPEAT 53..54
FT /note="4"
FT REPEAT 61..62
FT /note="5"
FT REPEAT 63..64
FT /note="6"
FT REPEAT 67..68
FT /note="7"
FT REPEAT 87..88
FT /note="8"
FT REPEAT 444..445
FT /note="9"
FT REGION 5..445
FT /note="9 X 2 AA repeats of F-G"
FT VAR_SEQ 1..180
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_008740"
FT VAR_SEQ 51..99
FT /note="GLFGGTQNKGFGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTT ->
FT A (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054355"
FT VAR_SEQ 353..388
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_008741"
FT CONFLICT 22..25
FT /note="AGGF -> GWV (in Ref. 1; AAF67488)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="N -> S (in Ref. 2; BAA91735)"
FT /evidence="ECO:0000305"
FT CONFLICT 265..277
FT /note="FEQANIKTQLQQL -> LNKPYKNTIAAT (in Ref. 1; AAF67488)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="L -> V (in Ref. 1; AAF67488)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="K -> T (in Ref. 1; AAF67488)"
FT /evidence="ECO:0000305"
FT CONFLICT 433
FT /note="E -> G (in Ref. 1; AAF67488)"
FT /evidence="ECO:0000305"
FT CONFLICT 507
FT /note="S -> G (in Ref. 3; CAD97957)"
FT /evidence="ECO:0000305"
FT STRAND 454..456
FT /evidence="ECO:0007829|PDB:4JNU"
FT HELIX 457..487
FT /evidence="ECO:0007829|PDB:4JNU"
FT HELIX 488..490
FT /evidence="ECO:0007829|PDB:4JNU"
SQ SEQUENCE 507 AA; 55435 MW; B5D235E01F1FE467 CRC64;
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG
FGFGTGFGTT TGTSTGLGTG LGTGLGFGGF NTQQQQQTTL GGLFSQPTQA PTQSNQLINT
ASALSAPTLL GDERDAILAK WNQLQAFWGT GKGYFNNNIP PVEFTQENPF CRFKAVGYSC
MPSNKDEDGL VVLVFNKKET EIRSQQQQLV ESLHKVLGGN QTLTVNVEGT KTLPDDQTEV
VIYVVERSPN GTSRRVPATT LYAHFEQANI KTQLQQLGVT LSMTRTELSP AQIKQLLQNP
PAGVDPIIWE QAKVDNPDSE KLIPVPMVGF KELLRRLKVQ DQMTKQHQTR LDIISEDISE
LQKNQTTSVA KIAQYKRKLM DLSHRTLQVL IKQEIQRKSG YAIQADEEQL RVQLDTIQGE
LNAPTQFKGR LNELMSQIRM QNHFGAVRSE ERYYIDADLL REIKQHLKQQ QEGLSHLISI
IKDDLEDIKL VEHGLNETIH IRGGVFS
