ID   NUP60_SCHPO             Reviewed;         736 AA.
AC   O74500;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Nucleoporin nup60;
DE   AltName: Full=Nuclear pore protein nup60;
GN   Name=nup60; ORFNames=SPCC285.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-159; SER-161 AND
RP   SER-162, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. Active directional transport is assured by both, a Phe-Gly
CC       (FG) repeat affinity gradient for these transport factors across the
CC       NPC and a transport cofactor concentration gradient across the nuclear
CC       envelope (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope. {ECO:0000250|UniProtKB:P39705}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic
CC       side {ECO:0000250}.
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DR   EMBL; CU329672; CAA20852.1; -; Genomic_DNA.
DR   PIR; T41259; T41259.
DR   RefSeq; NP_588341.1; NM_001023332.2.
DR   AlphaFoldDB; O74500; -.
DR   BioGRID; 275382; 108.
DR   STRING; 4896.SPCC285.13c.1; -.
DR   iPTMnet; O74500; -.
DR   MaxQB; O74500; -.
DR   PaxDb; O74500; -.
DR   PRIDE; O74500; -.
DR   EnsemblFungi; SPCC285.13c.1; SPCC285.13c.1:pep; SPCC285.13c.
DR   GeneID; 2538801; -.
DR   KEGG; spo:SPCC285.13c; -.
DR   PomBase; SPCC285.13c; nup60.
DR   VEuPathDB; FungiDB:SPCC285.13c; -.
DR   eggNOG; ENOG502T5TJ; Eukaryota.
DR   HOGENOM; CLU_381375_0_0_1; -.
DR   InParanoid; O74500; -.
DR   OMA; TMAHAPL; -.
DR   PRO; PR:O74500; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0140512; C:mitotic nuclear bridge midzone; IDA:PomBase.
DR   GO; GO:0140599; C:mitotic nuclear bridge midzone membrane domain; IDA:PomBase.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0044615; C:nuclear pore nuclear basket; IEA:InterPro.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; ISO:PomBase.
DR   GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR   GO; GO:0031990; P:mRNA export from nucleus in response to heat stress; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; ISO:PomBase.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0034398; P:telomere tethering at nuclear periphery; IBA:GO_Central.
DR   InterPro; IPR034432; Nup60.
DR   PANTHER; PTHR28284; PTHR28284; 1.
PE   1: Evidence at protein level;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..736
FT                   /note="Nucleoporin nup60"
FT                   /id="PRO_0000350997"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          647..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..695
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         157
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         159
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         161
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         162
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   736 AA;  80253 MW;  DA4D0C3A440ADA0F CRC64;
     MSSGPIRTLH KGKAARNRTP YDRIAASKDG NHSNGPQTPS KSIFQRAKEW LTPSSWKKAI
     SIFSSPVVNK HEDSFDSKTD EEYLQNVSTT TEDVSMLINT PVTEKYEQEH RDTSAQATPS
     IVEQSPNQML ANFFSKKGKT PLNEIEKEGI ISILNKSASP SSSVISPAAS LNRFQTPRAA
     AISKRESGVS SEPRARTSSL TPGNTPNSAK QWSAFRSTFS PLREQDQLST ISPNSLLPAQ
     RLSYYGPTLS TPYNRRLRHK RHSTTPISLS NSIAPSLSFQ PKKARYESAN VSFNDTSFTN
     VPTSSPLHQS TTANHPEKTP SRAAASLLSI LDSKEKNTPS ITAKAGSPQS APSKASYISP
     YARPGITTSR RRHDQIRPSS EKSEPEKKEP SAFETLEKSS NVQTYKPSLM PEFLEKASTH
     GSFAKQKEGE QTSLSEKTAL SEPENKTPVF SFKAPSATTD KPSPPVSSIF SFNAPSAAST
     KPSPAVSSTF SFNAPTTTPS ATSFSIINKE KPARSPNETI DVDLEEEGSG ISAEVEVANE
     GEDLQKNATE VKASTSEKPV FRFEAVTDEK NSEVSSSNQA SSSTMISQPN TGFSFGSFNK
     PAGQEEKPQQ RSLFSASFTT QKPELPAAKI EPEVQMTNVA IDQRSFEQAE KSPISVSEST
     SLVEVEKPSA EGTNEHKQDA TMTLEKTDKQ GSLEEEPFPK FSFTVLPKEN GENLSTMEST
     QELPKFSFSV LKEEKN