NUP75_DROME
ID NUP75_DROME Reviewed; 668 AA.
AC A1YK02; Q8SZH5;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Nuclear pore complex protein Nup75 {ECO:0000305};
DE AltName: Full=75 KDa Nucleoporin {ECO:0000312|FlyBase:FBgn0034310};
DE AltName: Full=Nucleoporin Nup75 {ECO:0000312|FlyBase:FBgn0034310};
DE AltName: Full=Nucleoporin Nup85 {ECO:0000305};
GN Name=Nup75 {ECO:0000312|FlyBase:FBgn0034310};
GN ORFNames=CG5733 {ECO:0000312|FlyBase:FBgn0034310};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL48509.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL48509.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL48509.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=20547758; DOI=10.1128/mcb.00124-10;
RA Chen X., Xu L.;
RT "Specific nucleoporin requirement for Smad nuclear translocation.";
RL Mol. Cell. Biol. 30:4022-4034(2010).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC) that seems to be
CC required for NPC assembly and maintenance (By similarity). Required for
CC nuclear import of phosphorylated Mad via importin msk
CC (PubMed:20547758). Has no role in classical nuclear localization signal
CC (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
CC Facilitates the interaction between Nup93 and sec13 with msk
CC (PubMed:20547758). {ECO:0000250|UniProtKB:Q9BW27,
CC ECO:0000269|PubMed:20547758}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). Component of the
CC NPC Nup107-160 subcomplex. {ECO:0000250|UniProtKB:Q9BW27}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q9BW27}. Nucleus membrane
CC {ECO:0000250|UniProtKB:Q9BW27}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup85 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57735.1; -; Genomic_DNA.
DR EMBL; AY070887; AAL48509.1; -; mRNA.
DR RefSeq; NP_611300.2; NM_137456.3.
DR AlphaFoldDB; A1YK02; -.
DR SMR; A1YK02; -.
DR IntAct; A1YK02; 2.
DR STRING; 7227.FBpp0085954; -.
DR PaxDb; A1YK02; -.
DR PRIDE; A1YK02; -.
DR EnsemblMetazoa; FBtr0086775; FBpp0085954; FBgn0034310.
DR GeneID; 37078; -.
DR KEGG; dme:Dmel_CG5733; -.
DR UCSC; CG5733-RA; d. melanogaster.
DR CTD; 37078; -.
DR FlyBase; FBgn0034310; Nup75.
DR VEuPathDB; VectorBase:FBgn0034310; -.
DR eggNOG; KOG2271; Eukaryota.
DR HOGENOM; CLU_027342_0_0_1; -.
DR InParanoid; A1YK02; -.
DR OMA; ELMEWLN; -.
DR OrthoDB; 588551at2759; -.
DR PhylomeDB; A1YK02; -.
DR Reactome; R-DME-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DME-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DME-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DME-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR SignaLink; A1YK02; -.
DR BioGRID-ORCS; 37078; 1 hit in 1 CRISPR screen.
DR ChiTaRS; Nup75; fly.
DR GenomeRNAi; 37078; -.
DR PRO; PR:A1YK02; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034310; Expressed in embryonic/larval hemocyte (Drosophila) and 22 other tissues.
DR ExpressionAtlas; A1YK02; baseline and differential.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031080; C:nuclear pore outer ring; ISS:FlyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:FlyBase.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IMP:FlyBase.
DR GO; GO:2000331; P:regulation of terminal button organization; IMP:FlyBase.
DR InterPro; IPR011502; Nucleoporin_Nup85.
DR PANTHER; PTHR13373; PTHR13373; 1.
DR Pfam; PF07575; Nucleopor_Nup85; 1.
PE 2: Evidence at transcript level;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..668
FT /note="Nuclear pore complex protein Nup75"
FT /id="PRO_0000440961"
FT CONFLICT 191
FT /note="G -> V (in Ref. 3; AAL48509)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 668 AA; 76872 MW; 3B1AEA3CE9A1F0D7 CRC64;
MSDSGVFAFE LGDDLATRCG NTLTGVFVPG SRIALSAYRH VTHSSRDEPT ENAGQVPVLI
YMAQESTLFD EPVLRSVLAE ANATFATLQQ LGSRATRAEY VNISRAYRSI VRSCLEKLEQ
AKKSPEVQTD EARLQRLCDA IVVFYAAECL WHLFEILYIQ SNQLVVPQLL DWARFHSPHA
EDRATDLLLM GEEASESDDY WSIVKSLIML GEIDVTRAVL SQNRKAGQTS FKAAEQILKS
MPVYQEGYAL QKFHSQWEFW HVDTERKIQS GLFATEPELE QLIRLVAGDS EQWDAGIKES
QDFYEYLPGY LLFTKPTCKP FELKIAAAKW LNRWCLLRPE REQCSMNRMV SQLMDHDLRL
FIYDAQKLND THWFSTHLID LIHHCGQLKS YFDQNNIDLP ALRHSMIYEY GSYLMTSHNM
WQLGIDYLDC CKQEGQAAIE LLLPRITLRS ERQATKLINL ARQRGLISVE REICKVLSKR
SYDNERYGNA LEWAIRSKDV LLVTAVADFI LKHYSKTGCM LCPDTIANVG GRMFASPRLV
FLSKYFEFYE FYRTRDFLSA SELLVNLLES KITPDYFWPS LLIDSMPLLE SKDPKIFAKE
TVAILHHIET DLVPIIERDV SKYGKHHTET VFKDYRVENV DEIMNLLRLA CARNLARALI
IENTLPVV
