ID   NUP82_CHATD             Reviewed;         882 AA.
AC   G0S4F3; G0ZGT7;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Nucleoporin NUP82 {ECO:0000303|PubMed:21784248};
DE   AltName: Full=Nuclear pore protein NUP82;
GN   Name=NUP82; ORFNames=CTHT_0022610;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. {ECO:0000250|UniProtKB:P40368}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope. Due to its 8-fold rotational
CC       symmetry, all subunits are present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:P40368, ECO:0000305|PubMed:21784248}.
CC   -!- INTERACTION:
CC       G0S4F3; G0SAK3: NUP145; NbExp=2; IntAct=EBI-16176422, EBI-16069276;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:P40368}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:P40368}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P40368}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P40368}.
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DR   EMBL; GL988041; EGS20431.1; -; Genomic_DNA.
DR   EMBL; JF276277; AEL00675.1; -; Genomic_DNA.
DR   RefSeq; XP_006692727.1; XM_006692664.1.
DR   PDB; 5CWW; X-ray; 2.20 A; B=1-595.
DR   PDBsum; 5CWW; -.
DR   AlphaFoldDB; G0S4F3; -.
DR   SMR; G0S4F3; -.
DR   DIP; DIP-61837N; -.
DR   IntAct; G0S4F3; 4.
DR   STRING; 759272.G0S4F3; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS20431; EGS20431; CTHT_0022610.
DR   GeneID; 18256299; -.
DR   KEGG; cthr:CTHT_0022610; -.
DR   eggNOG; ENOG502RXM6; Eukaryota.
DR   HOGENOM; CLU_009483_0_0_1; -.
DR   OrthoDB; 1149034at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:InterPro.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; IEA:InterPro.
DR   InterPro; IPR037700; NUP88/NUP82.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13257; PTHR13257; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Coiled coil; Membrane; mRNA transport; Nuclear pore complex;
KW   Nucleus; Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..882
FT                   /note="Nucleoporin NUP82"
FT                   /id="PRO_0000433172"
FT   REGION          76..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          676..762
FT                   /evidence="ECO:0000255"
FT   COILED          806..829
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        76..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           10..12
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           17..21
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          49..52
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          55..60
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          63..68
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           69..77
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          106..110
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          119..122
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          126..132
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          137..141
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           145..148
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          160..163
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   TURN            165..167
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          175..180
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           185..187
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          189..194
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          198..203
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           210..213
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          216..220
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           221..225
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           248..251
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          254..258
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           268..270
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          272..276
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          281..284
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          290..292
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           298..315
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           321..338
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          343..345
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          354..358
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          374..376
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           384..387
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          388..395
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          427..432
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          437..441
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          469..476
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           481..483
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          491..494
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          501..506
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          509..514
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           518..526
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   HELIX           534..543
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          547..554
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          566..570
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   TURN            571..573
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          574..580
FT                   /evidence="ECO:0007829|PDB:5CWW"
FT   STRAND          585..591
FT                   /evidence="ECO:0007829|PDB:5CWW"
SQ   SEQUENCE   882 AA;  98055 MW;  AACBA126097016E2 CRC64;
     MPKIKSFAPA WLNEPAPGHK LFAPAADDGT ATVPLAYGKK IKPGPRRTIA RRGTEIFVAC
     GKQIRWGDLA QLKESWESRP SRSSVGPTST KKDSSDFDDG AATAGYRIIK TPVADDIRQL
     VMSPNQDFLA VLTSHTVHIC ILPDSSHLHI QDTTPFKPKF WTLGPTTHVT SRSAVVSAVW
     HPLGVNGHAL VTVTEDAIVR VWELSTADRW TFDAPTLAID LKKLADATYL DQDFGVSTSA
     TNKGFSPDAF DMEVAAACFP TRDSGGWAPM TLWLAMTSGD VYALCPLLPQ RWTPPPTLIP
     SLSASIVAKV AAAEDNPEST PEERLVAQQQ LEWMSEIDNQ EPKLVEEATG EATIEVYTRP
     SRPGLVPKLQ GPFDFDLNPE DEQDDEVELK DIYVIGEKPR VADLMRGEEE ELEMMKEDQH
     NGLSLNIICL LSTSGQVKIC LDIDGVEAQW LPPRSKNKRL FAPPPEPPSL LTFQTFDTLK
     PAEVTPDGWP MFSEDATSPY SFYVTHPAGI TYISLTPWVF RLESELQSDS EAGTEFRIDL
     LAKGQGSERD RIFTQTRTQS PLAAATSIDD PDLGYFILSA TQTDPIALFF ETPERPVVPK
     ETSVVIPEHV EERPPSPYWE PRPLFHPAEA LDKPSAVPAW IDNLRTGRRR PLLTQELRLS
     MATLEVFHDG HKVVSTEVSD INDAVAELFR KCEALQGELR DQIKKVNEVK NRIHTITGDD
     LSDDPPVSED QLIKQRIRVA RERQEELANR MERLRKKFGR TTTRELSDKE KAWIEEVQNM
     ATSILGPEAG QGALATTPNL AKQPWKRLEE IKTLRNALMA EAEQLQKVGD DTEESTPASQ
     MPSLKIPSEI RKAKMAQVMS LLERESALVD AVKARIERLS IG