ID   NUP84_CHATD             Reviewed;         948 AA.
AC   G0SER9; G0ZGU7;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Nucleoporin NUP84 {ECO:0000303|PubMed:21784248};
DE   AltName: Full=Nuclear pore protein NUP84;
GN   Name=NUP84; ORFNames=CTHT_0059480;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. NUP84 is involved in nuclear poly(A)+ RNA export, in NPC
CC       assembly and distribution, as well as in nuclear envelope organization.
CC       {ECO:0000250|UniProtKB:P52891}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope. Due to its 8-fold rotational
CC       symmetry, all subunits are present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:P52891, ECO:0000305|PubMed:21784248}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:P52891}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:P52891}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P52891}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P52891}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:P52891}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P52891}; Nucleoplasmic side
CC       {ECO:0000250|UniProtKB:P52891}. Note=Symmetric distribution.
CC       {ECO:0000250|UniProtKB:P52891}.
CC   -!- SIMILARITY: Belongs to the Nup84/Nup107 nucleoporin family.
CC       {ECO:0000305}.
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DR   EMBL; GL988046; EGS17935.1; -; Genomic_DNA.
DR   EMBL; JF276290; AEL00685.1; -; Genomic_DNA.
DR   RefSeq; XP_006696266.1; XM_006696203.1.
DR   AlphaFoldDB; G0SER9; -.
DR   DIP; DIP-60569N; -.
DR   IntAct; G0SER9; 5.
DR   STRING; 759272.G0SER9; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS17935; EGS17935; CTHT_0059480.
DR   GeneID; 18259986; -.
DR   KEGG; cthr:CTHT_0059480; -.
DR   eggNOG; KOG1964; Eukaryota.
DR   HOGENOM; CLU_005882_1_0_1; -.
DR   OrthoDB; 671846at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007252; Nup84/Nup107.
DR   PANTHER; PTHR13003; PTHR13003; 1.
DR   Pfam; PF04121; Nup84_Nup100; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..948
FT                   /note="Nucleoporin NUP84"
FT                   /id="PRO_0000433188"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          118..148
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        6..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        940..948
FT                   /note="Missing (in Ref. 1; AEL00685)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   948 AA;  108081 MW;  5D58C105192A0BA1 CRC64;
     MSPAFNIPDS IESSRGSSQS PHHGLNPEEM ADIEATSQDN AVRVGEEIDY FAAQLDRYDA
     DQTGSPPERR SRAFQLVDSY YTFTRKRLDR LRERQARQRS AQRGSWQRAG SIEMDLDDAD
     EENDDILDEE LQQLEDEVQI WDLLRRILPL RYHDATQNQK KEHDGSTKSR RQWWNEFMVS
     DSVARERKVV LEWLQNSASY GPPIDEVVSD LQHNAERGDI LAHGWLHTRH KIKLQKSVNA
     YQGVLDPRDA AAAQSHLSSN SLITQLDPDA VTRQARKLEP QDESFERAIW LGCFEMLRRG
     CSMSEIREWL AVRTELWRAF SIAPLPLSNP DDEEQPDFDP VSLILWRRMC YAIATDGGTS
     DYDRAVYGLL AGDIPSVEKV CKTWDDVLFA HYNALLRTQF DLFLIKHGGD AAAKAAQQFP
     SFNAVAYHGD PATATKRLID SLETGMKTSA EAFRPAKALQ AAIVADDLDK FLFHQGLLLS
     IRANKKEKSK LIPEYPFPHE SFSDKKYYDL GDHQGLRILA HVLIIILTLD RLSGVAKDKG
     PLQARHQAAE NSIAAYISYL RLVRLEEMIP LYCSKLHGPR VYSTLSRNLI HIVDIDARLH
     QLTIMRNLGI DVSEFVKSQP LIYLDDVQDE LVSCDAKDQF KILEDGPATL KYGRLVKPDF
     FGDDADYVDP EDDALIRSME WLLLVPGLFV ETCAYAVRIY KYFLKRTRLR AARAFSRRVR
     GHEIIRTKFP NLLKDVDEND PAAWFEEFAA AQLPSDLLES CPASQEKLIT ITRHLWELES
     LVRALDSIET LTSLAALTRE ESVPMTREMW QEVSQTVRIA KACMRPVLKE WLLTTYDGRS
     VEQDFLDIRQ AYIPETILAY ISCLHFAGTS LSRDNLLECM DLAAIIAEKD SDVAKEFMRC
     GRMKELVEAF ASASKALAIW SGEKKGSQTN SKKLRELGWS RELWSIKS