NUP85_ARATH
ID NUP85_ARATH Reviewed; 716 AA.
AC Q8RXH2; O82634; Q9ASW9;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Nuclear pore complex protein NUP85;
DE AltName: Full=Nuclear pore complex protein NUP75 {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin 75;
DE AltName: Full=Nucleoporin 85;
GN Name=NUP85; Synonyms=NUP75 {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At4g32910 {ECO:0000312|Araport:AT4G32910};
GN ORFNames=F26P21.30 {ECO:0000312|EMBL:CAA21200.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX, SUBCELLULAR LOCATION, AND
RP NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- FUNCTION: Functions as component of the nuclear pore complex (NPC).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21189294}.
CC Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup85 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK32793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA21200.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g32910 has been split into 2 genes: At4g32910 and At4g32915.; Evidence={ECO:0000305};
CC Sequence=CAB80008.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g32910 has been split into 2 genes: At4g32910 and At4g32915.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL031804; CAA21200.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161582; CAB80008.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86142.1; -; Genomic_DNA.
DR EMBL; AF361625; AAK32793.1; ALT_INIT; mRNA.
DR EMBL; AY081256; AAL91145.1; -; mRNA.
DR EMBL; BT002244; AAN72255.1; -; mRNA.
DR RefSeq; NP_567908.1; NM_119444.4.
DR AlphaFoldDB; Q8RXH2; -.
DR SMR; Q8RXH2; -.
DR BioGRID; 14712; 22.
DR STRING; 3702.AT4G32910.1; -.
DR iPTMnet; Q8RXH2; -.
DR PaxDb; Q8RXH2; -.
DR PRIDE; Q8RXH2; -.
DR ProteomicsDB; 248751; -.
DR EnsemblPlants; AT4G32910.1; AT4G32910.1; AT4G32910.
DR GeneID; 829427; -.
DR Gramene; AT4G32910.1; AT4G32910.1; AT4G32910.
DR KEGG; ath:AT4G32910; -.
DR Araport; AT4G32910; -.
DR TAIR; locus:2123757; AT4G32910.
DR eggNOG; KOG2271; Eukaryota.
DR HOGENOM; CLU_024025_0_0_1; -.
DR InParanoid; Q8RXH2; -.
DR OMA; ELMEWLN; -.
DR OrthoDB; 588551at2759; -.
DR PhylomeDB; Q8RXH2; -.
DR PRO; PR:Q8RXH2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8RXH2; baseline and differential.
DR Genevisible; Q8RXH2; AT.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR InterPro; IPR011502; Nucleoporin_Nup85.
DR PANTHER; PTHR13373; PTHR13373; 1.
DR Pfam; PF07575; Nucleopor_Nup85; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..716
FT /note="Nuclear pore complex protein NUP85"
FT /id="PRO_0000413288"
SQ SEQUENCE 716 AA; 80849 MW; 9482ECBAF5DF521D CRC64;
MPGMSSESGG GELVLFSTKE KTPVLYPLSY GLKSPVHRLS ISWGCGNNLR VTVLRNPELR
DDDDGEVGGK VVNVRLSGED GEISDPQWRR IAYGSVSPFA LLQSRRNSIS SLSKMDMSSS
LYQTAWWEYV MEYSRDIKSL LSNTISLPAP LIEDPRSVIK NAEEPTSLKA AWELMELFYA
DKTCLSWLPE RLVDWLSEYD ILLSSSHPTI YSKLQDFQKE LVGLQAIEDD PRYWEVMASA
LSVGWLEIVV KLLHLHGSYQ LDQLGHRETE NGLVEAVAVL ISKMPRMRPQ LEDGKFGECS
AAKPDFMKTR ERWQSQITKL ECSAFWVQCA HHQTREGLRN MLKIMIGNAD CLRAATCNWM
ELFVSHLLYL RPFTKGLDGM HSLAQKCVQS KPVNTSHKLL RLLIGILGEN TEVVLAECSK
EFGSWMVAHA MELLTAGSEE GEVLVHEEQR KLGGINMEEL HRLVYAQVLS SHALTWQIAP
IYLASCEKQG LGLLELLFYR QPVQENQMLI KSLEICRLYE LSNVSAKLMK ISGVHHWKHG
RKGSGIFWLQ QARDENCLSV IAQQLFDSVG KSLSDESLKQ WEGLVELLGS ESQISGGLDF
LHKYRDFKRS LKVVHDGKTI DAAHEAVERL VSLMKSPSTP QRFWLPLLHD SLKLLNWPER
SLLNVTQTNL MLNKLQELSI ARLRPGFIES ELSAQAVGSV RLALATNLGR AFLEEC
