ID   NUP85_DANRE             Reviewed;         649 AA.
AC   Q6DBY0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Nuclear pore complex protein Nup85;
DE   AltName: Full=85 kDa nucleoporin;
DE   AltName: Full=Nucleoporin Nup85;
DE   AltName: Full=Pericentrin-1;
GN   Name=nup85; Synonyms=pcnt1; ORFNames=zgc:100943;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nuclear pore complex (NPC) that seems to be
CC       required for NPC assembly and maintenance (By similarity). Involved in
CC       nephrogenesis (By similarity). {ECO:0000250|UniProtKB:Q6DK84,
CC       ECO:0000250|UniProtKB:Q9BW27}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q9BW27}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:Q9BW27}.
CC   -!- SIMILARITY: Belongs to the nucleoporin Nup85 family. {ECO:0000305}.
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DR   EMBL; BC078318; AAH78318.1; -; mRNA.
DR   RefSeq; NP_001003625.1; NM_001003625.1.
DR   AlphaFoldDB; Q6DBY0; -.
DR   SMR; Q6DBY0; -.
DR   STRING; 7955.ENSDARP00000067719; -.
DR   PaxDb; Q6DBY0; -.
DR   GeneID; 445231; -.
DR   KEGG; dre:445231; -.
DR   CTD; 79902; -.
DR   ZFIN; ZDB-GENE-040801-145; nup85.
DR   eggNOG; KOG2271; Eukaryota.
DR   InParanoid; Q6DBY0; -.
DR   OrthoDB; 588551at2759; -.
DR   PhylomeDB; Q6DBY0; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-DRE-191859; snRNP Assembly.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR   Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q6DBY0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0072006; P:nephron development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR011502; Nucleoporin_Nup85.
DR   PANTHER; PTHR13373; PTHR13373; 1.
DR   Pfam; PF07575; Nucleopor_Nup85; 1.
PE   2: Evidence at transcript level;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..649
FT                   /note="Nuclear pore complex protein Nup85"
FT                   /id="PRO_0000324192"
SQ   SEQUENCE   649 AA;  74148 MW;  6F2ABF964724E588 CRC64;
     MEELDVEPST TLVPAAGVLQ KHLGFEWGPG DLLVYETNYK LRGSSSAGSP LVHVVRKDED
     ICSPILRKLF NESHLIFMGL QKIKEDAPSK NKKTQFVSIS RNYRSVIRAC MEELQQNAVT
     AQDGSLASQY GDQVSILLAI ELIWNLCEVL FIEAAPAGSL LLHLLNWVRL HKSDVDTRAR
     EVLQSENPTQ HPAYWDVVTS LVLQGRMDEA RQILSKQASL RMESSSVFKR MDTLLQTMPI
     FNPAGAQTLT EFDVKWRHWH EECDRCLQDH TFASSAELET LCKILLGDED VILEQKDLMS
     TWYHFLVSRL LFTHPTIKPP DLHYYAQSSM NMFLGPRATP EPLDIILLSA FEFDLHQVIK
     DCSIALNNWW FVAHLTDLLD HCKLLQSHNL HFGSNLREFL VLEYASGLFT HHSLWQLAVD
     YLDHCPEFGR VYLELQIERV PLDTERKANK VLRICEDRQM SEQVRSICKI MAKRALRNNR
     LGSALSWSIR AKDAALATLI SERFLQDYSN KGSFTDLDVL DNLGPAMLLS DRLTFLGKYR
     EFHRLYGENR FSDAAKLLLS LMMAKIAPRS LWMTLLTDAL PLLEQEEVIF TVDQTYELMS
     CLEELNSGTK DSNQMEQEED LESTKTELLR VALARNLATA IVKEGTIET