NUP85_DICDI
ID NUP85_DICDI Reviewed; 890 AA.
AC Q54NA0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Nuclear pore complex protein nup85;
DE AltName: Full=Nucleoporin nup85;
GN Name=nup85; ORFNames=DDB_G0285415;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the nuclear pore complex, a complex required for
CC the trafficking across the nuclear membrane.
CC {ECO:0000250|UniProtKB:P46673}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC passive diffusion of ions and small molecules and the active, nuclear
CC transport receptor-mediated bidirectional transport of macromolecules
CC such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC subunits across the nuclear envelope. Due to its 8-fold rotational
CC symmetry, all subunits are present with 8 copies or multiples thereof.
CC {ECO:0000250|UniProtKB:P46673}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P46673}. Nucleus membrane {ECO:0000250}.
CC -!- DOMAIN: Contains FG repeats.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup85 family. {ECO:0000305}.
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DR EMBL; AAFI02000079; EAL64782.1; -; Genomic_DNA.
DR RefSeq; XP_638280.1; XM_633188.1.
DR AlphaFoldDB; Q54NA0; -.
DR SMR; Q54NA0; -.
DR STRING; 44689.DDB0235247; -.
DR PaxDb; Q54NA0; -.
DR EnsemblProtists; EAL64782; EAL64782; DDB_G0285415.
DR GeneID; 8625088; -.
DR KEGG; ddi:DDB_G0285415; -.
DR dictyBase; DDB_G0285415; nup85.
DR eggNOG; KOG2271; Eukaryota.
DR HOGENOM; CLU_324513_0_0_1; -.
DR InParanoid; Q54NA0; -.
DR OMA; CILIARE; -.
DR PhylomeDB; Q54NA0; -.
DR PRO; PR:Q54NA0; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031080; C:nuclear pore outer ring; IDA:dictyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IDA:dictyBase.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR011502; Nucleoporin_Nup85.
DR PANTHER; PTHR13373; PTHR13373; 1.
DR Pfam; PF07575; Nucleopor_Nup85; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1..890
FT /note="Nuclear pore complex protein nup85"
FT /id="PRO_0000393275"
FT REPEAT 16..17
FT /note="1"
FT REPEAT 32..33
FT /note="2"
FT REPEAT 49..50
FT /note="3"
FT REPEAT 61..62
FT /note="4"
FT REPEAT 618..619
FT /note="5"
FT REGION 16..619
FT /note="5 X 2 AA repeats of F-G"
FT REGION 59..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 719..752
FT /evidence="ECO:0000255"
SQ SEQUENCE 890 AA; 101945 MW; AE8DFECF6AEC0986 CRC64;
MFSLNPQSNG NSNNLFGNVT LGNFSNNSNN LFGGSSTTST NTNNSNNLFG GSSTTNSNNL
FGSGGSSTTN NNNFNSNFNN NNIKNENKIK NGKKFYNFRW SPTGEILLYN TLNNFDNHNF
DQKNGGSDTI RYEMNTTLST IKKFYNDLYT NFETMQRIAG LSNQVIPDDR VREISHHSRT
YLSVILAAIN QMSKSQKTGS YIDDEDSCMN CDPLDNDLIK IQTPRVLEYF KQYPNKTLIF
FCGSIDSIYP YLCSKLSMET KSKCILIARE SNVPNSKRLD LIRTISNQGE LKILNKDEYS
NRYQIANENY GELDDVLTLE IDDTYLAYER EIDNLICMST MWRVANLFYF SVSSSSNSVS
PTQLLDCIEL ERKELLNSIE QQGTQDPMDS EYYNQIARLL VCGCIDQVIQ QLNILSRAPR
SASQIKSTSR KSPINLLIDI LSSIPLKKKS INGGGGAPLY PNEHLIQWNK WHQETQKILS
QYIESGSSST NQVDENLLPI VKILLGDQQT IMSTCNSFLQ LVVSNILFVE YTTSTTQLRQ
LFTQCYQTIQ APTTVDKIFL SFATKDLDIT LKKIFKHSPA WLAVHLSDLL YHHPYVMRKL
PNSESQLTNI REYLLSDFGQ SLASDSSLLS IGCNYLKYVK NGGLEMIDQF ISRQPIHFEK
NAIKMLDKWA TSVETKNSIY KMLSLQDFKR KRYAASLNWL MLANDNSHIT LLSNYLLENQ
LNSEFLNDLQ SLLEKNDEID CNINNNNNNN NNNNSNNRIS GNNNNNMIID ENKFEITNNS
ELIFLIRYRE LISLWKERSF KEYSSSLCLM FKDRVIPKRF WLRLLIDCVP LLESLKNLYF
TYQDTLLLQS CLEEIIQSHL FDQYSFNISN QDIQILRSAL ARNLAKSIIS
