ID   NUP85_XENLA             Reviewed;         653 AA.
AC   Q68FJ0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Nuclear pore complex protein Nup85;
DE   AltName: Full=85 kDa nucleoporin;
DE   AltName: Full=Nucleoporin Nup85;
GN   Name=nup85;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nuclear pore complex (NPC) that seems to be
CC       required for NPC assembly and maintenance (By similarity). Involved in
CC       nephrogenesis (By similarity). {ECO:0000250|UniProtKB:Q6DK84,
CC       ECO:0000250|UniProtKB:Q9BW27}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q9BW27}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:Q9BW27}.
CC   -!- SIMILARITY: Belongs to the nucleoporin Nup85 family. {ECO:0000305}.
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DR   EMBL; BC079790; AAH79790.1; -; mRNA.
DR   RefSeq; NP_001087440.1; NM_001093971.1.
DR   PDB; 6LK8; EM; 5.50 A; B/b=1-653.
DR   PDB; 7VCI; EM; 8.10 A; A/J=1-653.
DR   PDB; 7VOP; EM; 8.70 A; A/J=1-653.
DR   PDB; 7WB4; EM; 5.60 A; B/b=1-653.
DR   PDBsum; 6LK8; -.
DR   PDBsum; 7VCI; -.
DR   PDBsum; 7VOP; -.
DR   PDBsum; 7WB4; -.
DR   AlphaFoldDB; Q68FJ0; -.
DR   SMR; Q68FJ0; -.
DR   BioGRID; 104124; 2.
DR   DNASU; 447264; -.
DR   GeneID; 447264; -.
DR   KEGG; xla:447264; -.
DR   CTD; 447264; -.
DR   Xenbase; XB-GENE-1008056; nup85.L.
DR   OrthoDB; 588551at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447264; Expressed in testis and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0072006; P:nephron development; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011502; Nucleoporin_Nup85.
DR   PANTHER; PTHR13373; PTHR13373; 1.
DR   Pfam; PF07575; Nucleopor_Nup85; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..653
FT                   /note="Nuclear pore complex protein Nup85"
FT                   /id="PRO_0000324190"
SQ   SEQUENCE   653 AA;  75072 MW;  FB3A9A0E8A545354 CRC64;
     MEELDVDPAE TPIPGLGQQN RHIGFSWGPG DLLLYETLYQ KQGNSETAAR CPFMYLVRSD
     EDIYSPVLRK LFNESHSIFV GLQKSAEEAS GKSRKAQLVQ VSRNYRSVLR ACMEEMHTLS
     ESTRETAQKY ISQISILSAM ELSWNLCEIL FIESAPAGPL LILLLEWVRL HVCEVDNIVQ
     DVLRSEKPTE HEKFWDGVTG YVLQGRMNEA RQLLAKEAST SASARSMCRV LDDLLKKMPM
     LHTGGTQTLT EFELKWQHWR EECERHLQNG TFSSNVHMEA VCRVLLGDEE VLLEKRDLMT
     TWYHFLVSRL LFKHPTVKPT ELHFYAQSSL DMFLAGDSCP EPLDNILLAA FEFDIHQVIK
     EFSIVSSNWW FVAHLTDLLD HCQLFQAHNL YFGANMREFL LLDYASGLFS HHSLWQLGVD
     YFDYCPNLGR EYLKLHMERI PLSTEKKALK ALRICEQRQM TEQVRSICKT MAMQSLCNRR
     LGSALSWSIR AKDAAFATLI SDRFLKEYCE RGNFTDLDLI DNLGSAMLLS DRLTFLGKYR
     EFHRMYSQEQ FSEAASLLLS LMTARIAPCS FWLTLLLDAL PLLEQKQVIF SAEQTYELMR
     CLEDRMAAKL ESTSPDEIQK QDSSIDNTKV EMLRLALARN LARAIVTEGA LQE