NUP93_BOVIN
ID NUP93_BOVIN Reviewed; 819 AA.
AC A5PJZ5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Nuclear pore complex protein Nup93;
DE AltName: Full=93 kDa nucleoporin;
DE AltName: Full=Nucleoporin Nup93;
GN Name=NUP93;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly
CC and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to
CC the NPC. During renal development, regulates podocyte migration and
CC proliferation through SMAD4 signaling. {ECO:0000250|UniProtKB:Q8N1F7}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). Component of the p62
CC complex, a complex composed of NUP62 and NUP54. Forms a complex with
CC NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is
CC direct. Does not interact with TPR. Interacts with SMAD4 and IPO7;
CC translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation
CC resulting in activation of SMAD4 signaling.
CC {ECO:0000250|UniProtKB:Q8N1F7}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q66HC5};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q66HC5}. Nucleus,
CC nuclear pore complex {ECO:0000250|UniProtKB:Q8N1F7}. Nucleus envelope
CC {ECO:0000250|UniProtKB:Q8N1F7}. Note=Localizes at the nuclear basket
CC and at or near the nuclear entry to the gated channel of the pore.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC family. {ECO:0000305}.
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DR EMBL; BC142296; AAI42297.1; -; mRNA.
DR RefSeq; NP_001092391.1; NM_001098921.1.
DR AlphaFoldDB; A5PJZ5; -.
DR SMR; A5PJZ5; -.
DR STRING; 9913.ENSBTAP00000008683; -.
DR PaxDb; A5PJZ5; -.
DR PeptideAtlas; A5PJZ5; -.
DR PRIDE; A5PJZ5; -.
DR Ensembl; ENSBTAT00000008683; ENSBTAP00000008683; ENSBTAG00000006611.
DR Ensembl; ENSBTAT00000066921; ENSBTAP00000067770; ENSBTAG00000006611.
DR GeneID; 510004; -.
DR KEGG; bta:510004; -.
DR CTD; 9688; -.
DR VEuPathDB; HostDB:ENSBTAG00000006611; -.
DR VGNC; VGNC:32366; NUP93.
DR eggNOG; KOG2168; Eukaryota.
DR GeneTree; ENSGT00390000016353; -.
DR HOGENOM; CLU_011846_1_0_1; -.
DR InParanoid; A5PJZ5; -.
DR OMA; LLMCGQF; -.
DR OrthoDB; 187731at2759; -.
DR TreeFam; TF315118; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000006611; Expressed in oocyte and 107 other tissues.
DR ExpressionAtlas; A5PJZ5; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0034399; C:nuclear periphery; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISS:UniProtKB.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
DR InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR PANTHER; PTHR11225; PTHR11225; 1.
DR Pfam; PF04097; Nic96; 1.
PE 2: Evidence at transcript level;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..819
FT /note="Nuclear pore complex protein Nup93"
FT /id="PRO_0000356294"
FT MOD_RES 49
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 767
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
SQ SEQUENCE 819 AA; 93458 MW; 9B265F87969AF068 CRC64;
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDA GPPGRSSLDS
IEMAYARQIY IYNEKIVNGH LQPNLLDLCA SVTELDDKNI SDMWAMVKQM TDVLLVPATD
ALKSRNSVEV RMEFVRQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPIV PQISAPQSNK
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIDRLKLV
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS ATRPQRVIED
RDSQLRSQAR ALITFAGMIP YRTSGDTNAR LVQMEVLMN
