NUP93_DANRE
ID NUP93_DANRE Reviewed; 820 AA.
AC Q7ZU29; P79740; Q9DGQ8;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Nuclear pore complex protein Nup93;
DE AltName: Full=93 kDa nucleoporin;
DE AltName: Full=Dead eye protein;
DE AltName: Full=Nucleoporin Nup93;
GN Name=dye;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DISRUPTION PHENOTYPE.
RX PubMed=8985183; DOI=10.1101/gad.10.24.3141;
RA Allende M.L., Amsterdam A., Becker T., Kawakami K., Gaiano N., Hopkins N.;
RT "Insertional mutagenesis in zebrafish identifies two novel genes,
RT pescadillo and dead eye, essential for embryonic development.";
RL Genes Dev. 10:3141-3155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-60.
RA Kawakami K.;
RT "Danio rerio gene for dead eye, exon 1, 2, partial cds.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly
CC and/or maintenance. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}. Nucleus, nuclear pore complex
CC {ECO:0000250}. Note=Localizes at the nuclear basket and at or near the
CC nuclear entry to the gated channel of the pore. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Mutants can be recognized on day 2 of
CC embryogenesis by the presence of necrotic cells in the tectum and eyes.
CC Dye mutants die on day 5 of development. {ECO:0000269|PubMed:8985183}.
CC -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC family. {ECO:0000305}.
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DR EMBL; U77595; AAB61137.1; -; mRNA.
DR EMBL; BC044466; AAH44466.1; -; mRNA.
DR EMBL; AB047683; BAB12206.1; -; Genomic_DNA.
DR RefSeq; NP_571056.2; NM_130981.2.
DR AlphaFoldDB; Q7ZU29; -.
DR SMR; Q7ZU29; -.
DR STRING; 7955.ENSDARP00000013627; -.
DR PaxDb; Q7ZU29; -.
DR GeneID; 30172; -.
DR KEGG; dre:30172; -.
DR CTD; 9688; -.
DR ZFIN; ZDB-GENE-990415-46; nup93.
DR eggNOG; KOG2168; Eukaryota.
DR InParanoid; Q7ZU29; -.
DR OrthoDB; 187731at2759; -.
DR PhylomeDB; Q7ZU29; -.
DR Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DRE-191859; snRNP Assembly.
DR Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DRE-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:Q7ZU29; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0034399; C:nuclear periphery; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR PANTHER; PTHR11225; PTHR11225; 1.
DR Pfam; PF04097; Nic96; 1.
PE 2: Evidence at transcript level;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..820
FT /note="Nuclear pore complex protein Nup93"
FT /id="PRO_0000124785"
FT CONFLICT 37..38
FT /note="QQ -> HE (in Ref. 3; BAB12206)"
FT /evidence="ECO:0000305"
FT CONFLICT 251..253
FT /note="MQM -> TQV (in Ref. 1; AAB61137)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="R -> M (in Ref. 1; AAB61137)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="D -> G (in Ref. 1; AAB61137)"
FT /evidence="ECO:0000305"
FT CONFLICT 729
FT /note="E -> G (in Ref. 1; AAB61137)"
FT /evidence="ECO:0000305"
FT CONFLICT 776
FT /note="Q -> R (in Ref. 1; AAB61137)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 820 AA; 93149 MW; 3A72F8CCB2B80DB2 CRC64;
MDTEGFGELL QQAEQLAAET EAVSELPHVE RNLQEIQQAG ERLRSRTLTR TSQDTADVKA
SILLGSRGLD IFHISQRLES LSAATTFEPL EPVKDTDIQG FLKNERDNAL LSAIEESRRR
TFLLAEEYHR DSMLVQWEQV KQRVLHTLLG AGEDALDFSQ EVEPSFVSEV GVPGRSALDS
VEVAYSRQIY VFNEKIVNGH LQPNLGDLCA SVAESLDDKN VSEMWLMVKQ MTDVLLVPAK
DTLKSRVSVD MQMAFVRQAL QFLENSYKNY TLVTVFGNLH QAQLGGVPGT YQLVCSFLNI
KLPTPLPGRQ DGEVEGHPVW ALIYFCLRCG DLSAAMQVVN KAQHQLGDFK IWFQEYMNSP
DRRLSPATEN KLRLHYRRVL RNSADPYKRA VYCLIGKCDI GDNHGEVADK TEDYLWLKLN
QVCFDEDGSS SPQDRMTLAQ LQKQLLEDYG ESHFSASHQP FLYFQVLFLT AQFEAAIAFL
FRVERLRSHA VHVALVLYEL KLLLKSSGQS AQLLSQEAGD PPMVRRLNFI RLLMLYTRKF
ESTDPREALQ YFYFLRNEKD SQGENMFMRC VSELVIESRE FDMLLGRLEK DGSRKPGVID
KFAGDTRAII TKVASEAENK GLFEEAVKLY ELAKNADKVL ELMNKLLSPV IAQVSEPQSN
KERLKNMAVA IAERYRANGV AGEKSVDNTF YLLLDLMTFF DEYHAGHIDR AYDVIERLKL
VPLSQDSVEE RVAAFRNFSD EVRHNLSEVL LATMNILFTQ YKRLKGAAAG TPGRPQRTLE
DRDMLLRIQA RALITFAGMI PYRMAGDTNA RLVQMEVLMN
