NUP93_PONAB
ID NUP93_PONAB Reviewed; 819 AA.
AC Q5R822; Q5R8Y2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Nuclear pore complex protein Nup93;
DE AltName: Full=93 kDa nucleoporin;
DE AltName: Full=Nucleoporin Nup93;
GN Name=NUP93;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly
CC and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to
CC the NPC. During renal development, regulates podocyte migration and
CC proliferation through SMAD4 signaling. {ECO:0000250|UniProtKB:Q8N1F7}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). Component of the p62
CC complex, a complex composed of NUP62 and NUP54. Forms a complex with
CC NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is
CC direct. Does not interact with TPR. Interacts with SMAD4 and IPO7;
CC translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation
CC resulting in activation of SMAD4 signaling.
CC {ECO:0000250|UniProtKB:Q8N1F7}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q66HC5};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q66HC5}. Nucleus,
CC nuclear pore complex {ECO:0000250|UniProtKB:Q8N1F7}. Nucleus envelope
CC {ECO:0000250|UniProtKB:Q8N1F7}. Note=Localizes at the nuclear basket
CC and at or near the nuclear entry to the gated channel of the pore.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R822-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R822-2; Sequence=VSP_036026;
CC -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC family. {ECO:0000305}.
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DR EMBL; CR859615; CAH91778.1; -; mRNA.
DR EMBL; CR859933; CAH92088.1; -; mRNA.
DR RefSeq; NP_001126031.1; NM_001132559.2.
DR RefSeq; NP_001128848.1; NM_001135376.1.
DR AlphaFoldDB; Q5R822; -.
DR SMR; Q5R822; -.
DR STRING; 9601.ENSPPYP00000008332; -.
DR GeneID; 100172979; -.
DR GeneID; 100189766; -.
DR KEGG; pon:100172979; -.
DR CTD; 9688; -.
DR eggNOG; KOG2168; Eukaryota.
DR InParanoid; Q5R822; -.
DR OrthoDB; 187731at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0034399; C:nuclear periphery; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
DR InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR PANTHER; PTHR11225; PTHR11225; 1.
DR Pfam; PF04097; Nic96; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; mRNA transport; Nuclear pore complex;
KW Nucleus; Phosphoprotein; Protein transport; Reference proteome;
KW Translocation; Transport.
FT CHAIN 1..819
FT /note="Nuclear pore complex protein Nup93"
FT /id="PRO_0000356295"
FT MOD_RES 49
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT MOD_RES 767
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F7"
FT VAR_SEQ 784..819
FT /note="QLRSQACTLITFAGMIPYRTSGDTNARLVQMEVLMN -> GLALSPRLECND
FT TISARCNLHLLGSSHPPTSPSQVAGTTATPKSSPHPDYLCWNDTIPNVWGHQCEAGADG
FT GPHELSAMLWGCLSRHTVSTSGTWAH (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036026"
FT CONFLICT 199
FT /note="G -> R (in Ref. 1; CAH91778)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="S -> C (in Ref. 1; CAH92088)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="L -> P (in Ref. 1; CAH92088)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 819 AA; 93414 MW; 7B377F9D8D7DB040 CRC64;
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLCSRTLTR TSQETADVKA
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN
IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD
ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED
RDSQLRSQAC TLITFAGMIP YRTSGDTNAR LVQMEVLMN
