ID   NUP93_XENLA             Reviewed;         820 AA.
AC   Q7ZX96; P70035;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Nuclear pore complex protein Nup93;
DE   AltName: Full=93 kDa nucleoporin;
DE   AltName: Full=An4a;
DE   AltName: Full=Nucleoporin Nup93;
GN   Name=nup93;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Oocyte;
RX   PubMed=8952061;
RX   DOI=10.1002/(sici)1520-6408(1996)19:3<190::aid-dvg2>3.0.co;2-4;
RA   Hudson J.W., Alarcon V.B., Elinson R.P.;
RT   "Identification of new localized RNAs in the Xenopus oocyte by differential
RT   display PCR.";
RL   Dev. Genet. 19:190-198(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly
CC       and/or maintenance. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Nucleus, nuclear pore complex
CC       {ECO:0000250}. Note=Localizes at the nuclear basket and at or near the
CC       nuclear entry to the gated channel of the pore. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout early development, with
CC       embryonic expression primarily in anterior neural tissues.
CC       {ECO:0000269|PubMed:8952061}.
CC   -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC       family. {ECO:0000305}.
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DR   EMBL; U63919; AAB49669.1; -; mRNA.
DR   EMBL; BC045089; AAH45089.1; -; mRNA.
DR   RefSeq; NP_001080591.1; NM_001087122.1.
DR   PDB; 7VCI; EM; 8.10 A; U=1-820.
DR   PDB; 7VOP; EM; 8.70 A; U=1-820.
DR   PDB; 7WB4; EM; 5.60 A; L/O=1-820.
DR   PDB; 7WKK; EM; 4.20 A; C/E/c/e=1-820.
DR   PDBsum; 7VCI; -.
DR   PDBsum; 7VOP; -.
DR   PDBsum; 7WB4; -.
DR   PDBsum; 7WKK; -.
DR   AlphaFoldDB; Q7ZX96; -.
DR   SMR; Q7ZX96; -.
DR   BioGRID; 98525; 2.
DR   DIP; DIP-61693N; -.
DR   IntAct; Q7ZX96; 5.
DR   MINT; Q7ZX96; -.
DR   MaxQB; Q7ZX96; -.
DR   GeneID; 380283; -.
DR   KEGG; xla:380283; -.
DR   CTD; 380283; -.
DR   Xenbase; XB-GENE-5823157; nup93.L.
DR   OMA; LLMCGQF; -.
DR   OrthoDB; 187731at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 380283; Expressed in testis and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0034399; C:nuclear periphery; ISS:UniProtKB.
DR   GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR   PANTHER; PTHR11225; PTHR11225; 1.
DR   Pfam; PF04097; Nic96; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..820
FT                   /note="Nuclear pore complex protein Nup93"
FT                   /id="PRO_0000124784"
FT   CONFLICT        41
FT                   /note="E -> C (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        62..64
FT                   /note="VLL -> CTA (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="L -> H (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        305..306
FT                   /note="PI -> TV (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        404
FT                   /note="H -> N (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        433
FT                   /note="Q -> E (in Ref. 1; AAB49669)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   820 AA;  93454 MW;  12EDE67C51157D4A CRC64;
     MDGEGFGELL QQAEQLAAET EGVTELPHVE RNLQEIQQAG ERLRSKTMTR TSQESANVKA
     SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR
     TFVMAEEYHR ESMLVEWEQV KQRVLHTLLA SGEDALDFTQ ESETSYISES GAPGRSSLDN
     VEMAYARQMY MYNEKVVSGH LQPSLVDLCT EAAERLDDKN VSDLWVMVKQ MTDVPLIPAS
     DTLKSRCSGQ MQMAFVRQAL NYLEQSYKNY TLISVFANLQ QAQLGGVPGT YNLVRSFLNI
     RLPTPIPGLQ DGEIEGYPVW ALIYYCMRCG DLMAAQQVVN RAQHQLGDFK NCFQEYIHNK
     DRRLSPTTEN KLRLHYRRAV RASTDPYKRA VYCIIGRCDV SDNHSEVADK TEDYLWLKLS
     QVCFEDEANS SPQDRLTLPQ FQKQLFEDYG ESHFAVNQQP YLYFQVLFLT AQFEAAIAFL
     FRLERTRCHA VHVALALFEL KLLLKSTGQS AQLLSQEPGE PQGVRRLNFI RLLMLYTRKF
     EPTDPREALQ YFYFLRNEKD NQGESMFLRC VSELVIESRE FDMLLGKLEK DGSRKPGAID
     KFTRDTKTII NKVASVAENK GLFEEAAKLY DLAKNPDKVL ELTNKLLSPV VSQISAPQSN
     RERLKNMALA IAERYKSQGV SAEKSINSTF YLLLDLITFF DEYHAGHIDL SFDVIERLKL
     VPLSQDSVEE RVAAFRNFSD EIRHNLSEIL LATMNILFTQ YKRLKGSGPT TLGRPQRVQE
     DKDSVLRSQA RALITFAGMI PYRMSGDTNA RLVQMEVLMN