ID   NUP93_XENTR             Reviewed;         820 AA.
AC   Q6NX12;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Nuclear pore complex protein Nup93;
DE   AltName: Full=93 kDa nucleoporin;
DE   AltName: Full=Nucleoporin Nup93;
GN   Name=nup93;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly
CC       and/or maintenance. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Nucleus, nuclear pore complex
CC       {ECO:0000250}. Note=Localizes at the nuclear basket and at or near the
CC       nuclear entry to the gated channel of the pore. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC       family. {ECO:0000305}.
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DR   EMBL; BC067327; AAH67327.1; -; mRNA.
DR   RefSeq; NP_998879.1; NM_213714.1.
DR   AlphaFoldDB; Q6NX12; -.
DR   SMR; Q6NX12; -.
DR   STRING; 8364.ENSXETP00000039971; -.
DR   GeneID; 407948; -.
DR   KEGG; xtr:407948; -.
DR   CTD; 9688; -.
DR   Xenbase; XB-GENE-5823109; nup93.
DR   eggNOG; KOG2168; Eukaryota.
DR   InParanoid; Q6NX12; -.
DR   OrthoDB; 187731at2759; -.
DR   Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018461; Expressed in testis and 13 other tissues.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0034399; C:nuclear periphery; ISS:UniProtKB.
DR   GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR   GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR   PANTHER; PTHR11225; PTHR11225; 1.
DR   Pfam; PF04097; Nic96; 1.
PE   2: Evidence at transcript level;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..820
FT                   /note="Nuclear pore complex protein Nup93"
FT                   /id="PRO_0000356297"
SQ   SEQUENCE   820 AA;  93354 MW;  2984D6072677795E CRC64;
     MDGEGFGELL QQAEQLAAET EGVTELPHVE RNLQEIQQAG ERLRSKTMTR TSQESANVKA
     SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR
     TFVMAEEYHR ESMLVEWEQV KQRVLHTLLA SGEDALDFTQ ESETSYISES GAPGRSSLDN
     VEMAYARQIY MYNEKVVSGH LQPSLVELCT EAAERLDDKN VSDLWVMVKQ MTDVPLIPAS
     DSLKSRCSVQ MQMAFLRQAL HFLEQSYKNY TLMSVFANLQ QAQLGGVPGT YNLVRSFLNI
     RLPAPIPGLQ DGEVEGYPVW ALIYYCMRCG DLMAAQQVVN RAQHQLGDFK NCFQEYVHSK
     DRRLSPTTEN KLRLHYRRAV RASTDPYKRV VYCIIGRCDV TDNHSEVADK TEDYLWLKLS
     QVCFEDEANS SPQDRLTLPQ FQKQLFEDYG ESHFAVNQQP YLYFQVLFLT AQFEAAIAFL
     FRLERTRCHA VHVALALFEL KLLLKSTGQS AQLLSLEPGD PQGVRHLNFI RLLMLYTRKF
     EPTDPREALQ YFYFLRNEKD SQGESMFLRC VSELVIESRE FDMLLGKLEK DGSRKPGAID
     KFTRDTKTII NKVASVAENK GLFEEAAKLY DLAKNPDKVL ELTNKLLSPV VSQISAPQSN
     RERLKNMALA IAERYKSQGV SAEKSINSTF YLLLDLITFF DEYHAGHVDL AFDVIERLKL
     VPLSQDSVEE RVAAFRNFSD EIRHNLSEIL LATMNILFTQ YKRLKGSGPN TLGRPQRAQE
     DKDSVLRSQA RALITFAGMI PYRMSGDTNA RLVQMEVLMN