NUP98_DICDI
ID NUP98_DICDI Reviewed; 2053 AA.
AC Q54EQ8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Nuclear pore complex protein Nup98-Nup96;
DE Contains:
DE RecName: Full=Nuclear pore complex protein Nup98;
DE AltName: Full=Nucleoporin Nup98;
DE Contains:
DE RecName: Full=Nuclear pore complex protein Nup96;
DE AltName: Full=Nucleoporin Nup96;
DE Flags: Precursor;
GN Name=nup98; ORFNames=DDB_G0291390;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Nup98 and Nup96 play a role in the bidirectional transport
CC across the nucleoporin complex (NPC). The repeat domain in Nup98 has a
CC direct role in the transport (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Nup98 interacts directly with Nup96. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic
CC side {ECO:0000250}. Note=Nup96 is localized to the nucleoplasmic side
CC of the nuclear pore complex, at or near the nucleoplasmic basket.
CC {ECO:0000250}.
CC -!- DOMAIN: Contains G-L-F-G repeats.
CC -!- PTM: Autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98
CC only, respectively. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleoporin GLFG family. {ECO:0000305}.
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DR EMBL; AAFI02000177; EAL61679.1; -; Genomic_DNA.
DR RefSeq; XP_635182.1; XM_630090.1.
DR AlphaFoldDB; Q54EQ8; -.
DR SMR; Q54EQ8; -.
DR STRING; 44689.DDB0235244; -.
DR MEROPS; S59.A08; -.
DR PaxDb; Q54EQ8; -.
DR PRIDE; Q54EQ8; -.
DR EnsemblProtists; EAL61679; EAL61679; DDB_G0291390.
DR GeneID; 8628128; -.
DR KEGG; ddi:DDB_G0291390; -.
DR dictyBase; DDB_G0291390; nup98.
DR eggNOG; KOG0845; Eukaryota.
DR HOGENOM; CLU_002330_1_0_1; -.
DR InParanoid; Q54EQ8; -.
DR OMA; KGFEWPY; -.
DR PhylomeDB; Q54EQ8; -.
DR PRO; PR:Q54EQ8; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; ISS:dictyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:dictyBase.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0051292; P:nuclear pore complex assembly; ISS:dictyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1610.10; -; 1.
DR InterPro; IPR025574; Nucleoporin_FG_rpt.
DR InterPro; IPR037665; Nucleoporin_S59-like.
DR InterPro; IPR037637; NUP98-NUP96.
DR InterPro; IPR007230; Nup98_auto-Pept-S59_dom.
DR InterPro; IPR036903; Nup98_auto-Pept-S59_dom_sf.
DR InterPro; IPR021967; Nup98_C.
DR PANTHER; PTHR23198; PTHR23198; 2.
DR PANTHER; PTHR23198:SF17; PTHR23198:SF17; 2.
DR Pfam; PF04096; Nucleoporin2; 1.
DR Pfam; PF13634; Nucleoporin_FG; 5.
DR Pfam; PF12110; Nup96; 1.
DR SUPFAM; SSF82215; SSF82215; 1.
DR PROSITE; PS51434; NUP_C; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage; Membrane; mRNA transport; Nuclear pore complex;
KW Nucleus; Protein transport; Reference proteome; Repeat; Translocation;
KW Transport.
FT CHAIN 1..1164
FT /note="Nuclear pore complex protein Nup98"
FT /id="PRO_0000328562"
FT CHAIN 1165..2053
FT /note="Nuclear pore complex protein Nup96"
FT /id="PRO_0000328563"
FT DOMAIN 1025..1164
FT /note="Peptidase S59"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00765"
FT REGION 43..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1011
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2053 AA; 220551 MW; EC1FCB411A2E6A85 CRC64;
MFGGQFGSFG AKPAATASPF GAPSAAPTTS LFGSTAPSSG FGGFGSTAQT TQPTTGGFGG
FGGFGGATTT QQPAASPFGG GGTGGSGLFG SSAQTTTQQP GASPFGGGFG TTTTTTTQQP
GASPFGGTGG GLFGSSAQTT TQQQGASPFG GFGGATTTQP SLLSGATGGF GGFGGSTTSG
TQLGGGGGAT SGAFGGSSSP FGGSGGATTS SPFGGGGGSF GATTQKQYGT PIPYQQTTIE
GNTFVSISAM PQYNDRSFEE LRFEDITHRK DIVYKTGGGS GGGNSLFGST PTTQPSSPFG
AQTTTQTTGG LFGGQTTTSP FGGQTSATPG SSLFGSTQPT QQQTSGGLFG SVQPTQQQAG
GGLFGSMPST GGSSLFGSTQ PTQQQTGGAQ PTQSLFGGQT QTTTSPFGSQ TSTPFGQPQQ
TNTGSGLFGA QQTQQTNTGG GLFGAQPTQQ TSGGGLFGTQ PTSGTGLFGT SPTAGGTGLF
GTTQPTSQGT GLFGTTQPTT QGTGLFGTSP TSGTGLFGST PTSGTGLFGS TPTSGTGLFG
SAQPPQNQQS QTSLFGNTGT GATNTGTGLF GSAQPSSNPG GGLFGSAQPS TTTGGLFGSN
QPTAQPTTSL FGNTTGSVGG LGATPNITSG LFGSNPAQTG GLFGSTQPTT QTSLFGNTGS
TGGLGAQNGG GLFGNLSQPT ATAGQGLSGG LFGNLSQPTA TAGQGLSSGG LFGNTLLGQP
STQGLSSALP TLGLGLMGGQ PQQTQQLPQG SLMLQQTQQP LQQQPLQQQQ QPLQQSTIQL
NNQINSASPY FPISSPAPFA TFVKDLTSTS KVVSPPSYTQ RSLSHHGYIP KSTTKLVPRR
GPNNVDLGFS VIQNQNGLFP IDKFITKHSK SLNINTTNET EDTLRSLNTK SSSLFNNNNN
NNNNNNNRNV NTNVNDYQNN GLPSSSLYNS NINQLSNNNN NNNNIYNNNN NNNINNNNNN
NNISTQFNLR NNQSSSDNLN NDKSLSSSSS NKSQQQQQKE QKEEQPPKPI KEKEFINPNA
PKLTRDGYQC VPSIKELSKK TDKELSSVQG FTISRDGCGS IYFPGSTNLV ALDLDDIVDI
EPREVSVYKD EETKPEIGYG LNRDAVVTLE NCWPKNKNGE VVKEDGTILD KYENALKKVS
AKSDCGFVSY SRSNGTWVFT VKHFSKYSAP DFDEDDQQMQ QQTQQKQQQT QPSKVTFQQP
STKLTKPKFT ANLDNFDSDS ETSSGDENQD EMVPQKKTPF IKRVSNRESG LFDTPSVVPM
SEKIETTPSK IARVSEPTSQ SSRMSNNALK FSTFNPQQQQ LQSSRFKSTG LSILSNPVKN
LIQSDVNNEQ SMFSNTTTTS TTRIQPLPSQ QHLVQPIPTT ISLNKNYFSK VRIDPQVYDR
IVPKEESITN QYRMKNERLN HSTQDVSLFM RRSFRVGWAP GGKLISITKS SFKNLLIKKL
PTDTKEDKKE SIIKFLKNHH SHSSLVPENL KSIGWFSISN VQEQIESQLT LNVPSSQSVY
YNRIWSLISN LWGNVLKGNG SKYINTNYSE DTIRKLNLNQ WLKDVIAPLL RDEMDSLRKK
TNSNYLEQIF SYLSAKQIKE ASDLANENKD FRLATMMSQI WSSSESGKEL ILKQLTTYHS
NGSDEFINEK RLEILHLIAG SVNKIYKNLN DWIRCFAVSF WFKYSLEYSI EDSVENFERS
FNAHRSVYPL PPYLIKSTST NSKQIEEQQH YYDICFLLLK LFAVNRGSSH FDKFKNIFYP
ENIGQDLLDY HLSWNLYTVL KSIPSLNKQP DLVNASNLHS SFALQLERLG LWQWSIYVLL
HTPDQSNHVR EEAVKSLIAR AAPVITSEDR VFLTTKLHIP EIWIDEAKAW YSGYDCNNDI
YDQIDALFKS YQYTKIHDII FSNIGPNYII QKRYHSLKDL LIRLEPHSSF ISTWRYGGSI
FLEFADICIQ YKEILSQLSN TAEEIQRTKY YVNLKDITTR IVNILSDISK ITQSSEIKNT
SASYKQSLSF MSEALITKAS LLRDLPESIV KLVSTNNLVS TLNSLPLTQD YRSKNLESLT
DQIQDTLLNS IYQ
