ID   ARP6_ASPFU              Reviewed;         468 AA.
AC   Q4W9M3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Actin-like protein arp6;
GN   Name=arp6; ORFNames=AFUA_4G04420;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; AAHF01000016; EAL84590.1; -; Genomic_DNA.
DR   RefSeq; XP_746628.1; XM_741535.1.
DR   AlphaFoldDB; Q4W9M3; -.
DR   SMR; Q4W9M3; -.
DR   STRING; 746128.CADAFUBP00009580; -.
DR   EnsemblFungi; EAL84590; EAL84590; AFUA_4G04420.
DR   GeneID; 3503987; -.
DR   KEGG; afm:AFUA_4G04420; -.
DR   VEuPathDB; FungiDB:Afu4g04420; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; Q4W9M3; -.
DR   OMA; FFEEYEC; -.
DR   OrthoDB; 649708at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..468
FT                   /note="Actin-like protein arp6"
FT                   /id="PRO_0000089111"
SQ   SEQUENCE   468 AA;  51791 MW;  BFBAC9E4DD07AF70 CRC64;
     MGSTKPRTSA QASAPKVQSL PEKTFIIDNG AYTLKAGYAP GFPPPEDLGQ ALSACSTIPN
     AIAKTRGNRI YIGAQLNSQV TDWNEMVFRR PVEKGYIVNW EAQKEIWDNA FFDEKTVRSK
     DLRIESPEDT TLVLTEAPNA LPTLQKNADE IVMEEWGFGG YVRFVGPVLN AWNEVQSLFG
     DPIGQDSSSP ISPKQCLLVV DSGYSHTTVT PVYKGQPIQR AIRRLDIGGK HLTNYLKEMV
     SMRQYNMVDE TYIMNEVKEA VCFVSNNFAG DLEQTWQGNR KRGLTDAAEG ITVDYVLPDP
     NTGKKGFMRP HDPLSNAKKR KSILSGGNAE ALSEDVLILG NERFTVPEIL FTPSDIGMKQ
     AGIPDIILQS LSVLPTGLHP SFLANVLVVG GNTLIPGFLE RLESELRQIA SAECVVRVRR
     PHDPIRSTWL GASRLAANRA ELRKFAITRQ EYQEYGSSWA GRKFSGIL