ID   NUPB_LACLM              Reviewed;         364 AA.
AC   A2RKA6;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Nucleoside ABC transporter permease protein NupB {ECO:0000305};
GN   Name=nupB {ECO:0000303|PubMed:20595258};
GN   OrderedLocusNames=llmg_1122 {ECO:0000312|EMBL:CAL97716.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=MG1363;
RX   PubMed=20595258; DOI=10.1099/mic.0.039818-0;
RA   Martinussen J., Soerensen C., Jendresen C.B., Kilstrup M.;
RT   "Two nucleoside transporters in Lactococcus lactis with different substrate
RT   specificities.";
RL   Microbiology 156:3148-3157(2010).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in the uptake of
CC       all common nucleosides (PubMed:20595258). Responsible for the
CC       translocation of the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:20595258, ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NupA),
CC       two transmembrane proteins (NupB and NupC) and a solute-binding protein
CC       (BmpA). {ECO:0000305|PubMed:20595258}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:20595258}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM406671; CAL97716.1; -; Genomic_DNA.
DR   RefSeq; WP_011835027.1; NZ_WJVF01000012.1.
DR   AlphaFoldDB; A2RKA6; -.
DR   STRING; 416870.llmg_1122; -.
DR   TCDB; 3.A.1.2.17; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; CAL97716; CAL97716; llmg_1122.
DR   KEGG; llm:llmg_1122; -.
DR   eggNOG; COG4603; Bacteria.
DR   HOGENOM; CLU_040769_0_1_9; -.
DR   OMA; FRMNLFN; -.
DR   PhylomeDB; A2RKA6; -.
DR   BioCyc; LLAC416870:LLMG_RS05700-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..364
FT                   /note="Nucleoside ABC transporter permease protein NupB"
FT                   /id="PRO_0000449274"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   364 AA;  38876 MW;  2B0C5F2DFFFFD06A CRC64;
     MNNKTRKVLV PLIAIVFGFL LGAIIMLAFG YNPIWGYEDL FISALGSARS IGETLQTMGP
     LILTALSFAV AMKVGLFNIG MSGQALAGWI SSMWFALSFP DIPRLLMIPL VVIIGMVFGA
     FMGFIPGILR ALLGTSEVIT TIMLNYIMLF FSTFMIHSMF QKNILMDNTT DQTKLISANA
     SFRTNWMSSL TDNSTLNIGL IIAIIALVIM AIIFTKTTLG FEIKAVGLNP DASEYAGISA
     KRTLILSMVV AGALAGLGGV VYGFGYMQNF VSQSASLDIG FYGMAVALLG GNSPIGILFA
     ALLFSVLQTG APGMTNDGIP PEIVKVVTAA IIFFIAVKFI IEVMLPKAKA IKASEATKKK
     GEKA