NUPC_BACSU
ID NUPC_BACSU Reviewed; 393 AA.
AC P39141; O32288;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 4.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Nucleoside permease NupC {ECO:0000305};
GN Name=nupC {ECO:0000303|PubMed:8550462}; OrderedLocusNames=BSU39410;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC STRAIN=168;
RX PubMed=8550462; DOI=10.1128/jb.178.2.424-434.1996;
RA Saxild H.H., Andersen L.N., Hammer K.;
RT "Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction
RT by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded
RT DeoR repressor protein.";
RL J. Bacteriol. 178:424-434(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT between the iol and hut operons.";
RL DNA Res. 2:295-301(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 16.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- FUNCTION: Transport of the pyrimidine nucleoside uridine.
CC {ECO:0000269|PubMed:8550462}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Induced by deoxyadenosine and thymidine. Repressed by DeoR
CC and glucose. {ECO:0000269|PubMed:8550462}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000305}.
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DR EMBL; X82174; CAA57663.1; -; Genomic_DNA.
DR EMBL; D45912; BAA08338.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15977.2; -; Genomic_DNA.
DR PIR; S78769; S49456.
DR RefSeq; NP_391820.2; NC_000964.3.
DR RefSeq; WP_003244143.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P39141; -.
DR SMR; P39141; -.
DR STRING; 224308.BSU39410; -.
DR TCDB; 2.A.41.1.2; the concentrative nucleoside transporter (cnt) family.
DR jPOST; P39141; -.
DR PaxDb; P39141; -.
DR PRIDE; P39141; -.
DR EnsemblBacteria; CAB15977; CAB15977; BSU_39410.
DR GeneID; 937534; -.
DR KEGG; bsu:BSU39410; -.
DR PATRIC; fig|224308.179.peg.4266; -.
DR eggNOG; COG1972; Bacteria.
DR InParanoid; P39141; -.
DR OMA; WFFLNSN; -.
DR PhylomeDB; P39141; -.
DR BioCyc; BSUB:BSU39410-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:1901642; P:nucleoside transmembrane transport; IBA:GO_Central.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR PANTHER; PTHR10590; PTHR10590; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
DR TIGRFAMs; TIGR00804; nupC; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..393
FT /note="Nucleoside permease NupC"
FT /id="PRO_0000070453"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 16
FT /note="L -> F (in Ref. 1; CAA57663)"
FT /evidence="ECO:0000305"
FT CONFLICT 304..305
FT /note="SI -> RL (in Ref. 1; CAA57663)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="S -> V (in Ref. 1; CAA57663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 42496 MW; ADE758D1330842A6 CRC64;
MKYLIGIIGL IVFLGLAWIA SSGKKRIKIR PIVVMLILQF ILGYILLNTG IGNFLVGGFA
KGFGYLLEYA AEGINFVFGG LVNADQTTFF MNVLLPIVFI SALIGILQKW KVLPFIIRYI
GLALSKVNGM GRLESYNAVA SAILGQSEVF ISLKKELGLL NQQRLYTLCA SAMSTVSMSI
VGAYMTMLKP EYVVTALVLN LFGGFIIASI INPYEVAKEE DMLRVEEEEK QSFFEVLGEY
ILDGFKVAVV VAAMLIGFVA IIALINGIFN AVFGISFQGI LGYVFAPFAF LVGIPWNEAV
NAGSIMATKM VSNEFVAMTS LTQNGFHFSG RTTAIVSVFL VSFANFSSIG IIAGAVKGLN
EKQGNVVARF GLKLLYGATL VSFLSAAIVG LIY
