NUPC_HELPY
ID NUPC_HELPY Reviewed; 418 AA.
AC O25792;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Nucleoside permease NupC {ECO:0000305};
GN Name=nupC {ECO:0000303|PubMed:22701700};
GN OrderedLocusNames=HP_1180 {ECO:0000312|EMBL:AAD08224.1};
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=22701700; DOI=10.1371/journal.pone.0038727;
RA Miller E.F., Vaish S., Maier R.J.;
RT "Efficiency of purine utilization by Helicobacter pylori: roles for
RT adenosine deaminase and a NupC homolog.";
RL PLoS ONE 7:E38727-E38727(2012).
CC -!- FUNCTION: Involved in purine nucleosides uptake. Could also be involved
CC in uptake of nucleobases. {ECO:0000269|PubMed:22701700}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mutant is deficient for transport of inosine,
CC guanosine or adenosine. {ECO:0000269|PubMed:22701700}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08224.1; -; Genomic_DNA.
DR PIR; D64667; D64667.
DR RefSeq; NP_207971.1; NC_000915.1.
DR RefSeq; WP_000577889.1; NC_018939.1.
DR AlphaFoldDB; O25792; -.
DR SMR; O25792; -.
DR IntAct; O25792; 1.
DR STRING; 85962.C694_06100; -.
DR PaxDb; O25792; -.
DR EnsemblBacteria; AAD08224; AAD08224; HP_1180.
DR KEGG; hpy:HP_1180; -.
DR PATRIC; fig|85962.47.peg.1268; -.
DR eggNOG; COG1972; Bacteria.
DR OMA; IVWHTVI; -.
DR PhylomeDB; O25792; -.
DR BioCyc; MetaCyc:HP_RS05795-MON; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:1901642; P:nucleoside transmembrane transport; IBA:GO_Central.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR PANTHER; PTHR10590; PTHR10590; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
DR TIGRFAMs; TIGR00804; nupC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..418
FT /note="Nucleoside permease NupC"
FT /id="PRO_0000435285"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 418 AA; 43807 MW; FA36B16734C330A8 CRC64;
MIFSSLFSVV GMAVLFLIAW VFSSNKRAIN YRTIVSAFVI QVALGALALY VPLGREMLQG
LASGIQSVIS YGYEGVRFLF GNLAPNAKGD QGIGGFVFAI NVLAIIIFFA SLISLLYYLK
IMPLFINLIG GALQKCLGTS RAESMSAAAN IFVAHTEAPL VIKPYLKSMS DSEIFAVMCV
GMASVAGPVL AGYASMGIPL PYLIAASFMS APGGLLFAKI IYPQNETISS HADVSIEKHV
NAIEAIANGA STGLNLALHV GAMLLAFVGM LALINGLLGV VGGFLGMEHL SLGLILGTLL
KPLAFMLGIP WSQAGIAGEI IGIKIALNEF VGYMQLLPYL GDNPPLILSE KTKAIITFAL
CGFANLSSVA MLIGGLGSLV PKKKDLIVRL ALKAVLVGTL SNFMSATIAG LFIGLNAH
