ID   NUPC_LACLM              Reviewed;         317 AA.
AC   A2RKA5;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Nucleoside ABC transporter permease protein NupC {ECO:0000305};
GN   Name=nupC {ECO:0000303|PubMed:20595258};
GN   OrderedLocusNames=llmg_1121 {ECO:0000312|EMBL:CAL97715.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=MG1363;
RX   PubMed=20595258; DOI=10.1099/mic.0.039818-0;
RA   Martinussen J., Soerensen C., Jendresen C.B., Kilstrup M.;
RT   "Two nucleoside transporters in Lactococcus lactis with different substrate
RT   specificities.";
RL   Microbiology 156:3148-3157(2010).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in the uptake of
CC       all common nucleosides (PubMed:20595258). Responsible for the
CC       translocation of the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:20595258, ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NupA),
CC       two transmembrane proteins (NupB and NupC) and a solute-binding protein
CC       (BmpA). {ECO:0000305|PubMed:20595258}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:20595258}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AM406671; CAL97715.1; -; Genomic_DNA.
DR   RefSeq; WP_011676327.1; NZ_WJVF01000012.1.
DR   AlphaFoldDB; A2RKA5; -.
DR   STRING; 416870.llmg_1121; -.
DR   TCDB; 3.A.1.2.17; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; CAL97715; CAL97715; llmg_1121.
DR   GeneID; 61109608; -.
DR   KEGG; llm:llmg_1121; -.
DR   eggNOG; COG1079; Bacteria.
DR   HOGENOM; CLU_040769_1_2_9; -.
DR   OMA; MIFGNWM; -.
DR   PhylomeDB; A2RKA5; -.
DR   BioCyc; LLAC416870:LLMG_RS05695-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..317
FT                   /note="Nucleoside ABC transporter permease protein NupC"
FT                   /id="PRO_0000449275"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  33552 MW;  1847D09B410A51BB CRC64;
     MNVVNTLQII VANMLIYSTP LIFTSIGGVF SERGGIVNVG LEGIMTIGAF SSVVFNLTTA
     GMFGSMTPWL SILFGALIGA LFSSLHAVAT VNLRADHIVS GTVLNLMAPA LGVFLLQVFY
     QQGQININEQ IGYWNVPLLS NIPVIGKIFF TQTSLPGFLA IVVAILAWYV LFKTRFGLRL
     RSVGENPQAA DTLGINVYAY RWAGVLLSGV LGGVGGAIYA QAISGNFSVS TIAGQGFISL
     AAMIFGKWNP IGAMLSSLLF GLFTSLAVVG GQIPGIKEIP SSFLQMAPYV FTIIVLALFL
     GKAIAPKADG VNYIKSK